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Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50191606
Substrate
n/a
Meas. Tech.
ChEMBL_456953 (CHEMBL924315)
EC50
>10000±n/a nM
Citation
 Ahn, JH; Shin, MS; Jung, SH; Kim, JA; Kim, HM; Kim, SH; Kang, SK; Kim, KR; Rhee, SD; Park, SD; Lee, JM; Lee, JH; Cheon, HG; Kim, SS Synthesis and structure-activity relationship of novel indene N-oxide derivatives as potent peroxisome proliferator activated receptor gamma (PPARgamma) agonists. Bioorg Med Chem Lett 17:5239-44 (2007) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Homo sapiens (Human)
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM50191606
Synonyms:
1-hydroxyimino-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester | CHEMBL250822 | CHEMBL413047
Type:
Small organic molecule
Emp. Form.:
C19H17NO4
Mol. Mass.:
323.3426
SMILES:
CCOC(=O)C1=C(c2ccc(OC)cc2C1N=O)c1ccccc1 |t:5|
Structure:
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