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Found 413 with Last Name = 'cheon' and Initial = 'hg'
TargetDipeptidyl peptidase 4(Sus scrofa (pig))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50206821((R)-3-amino-1-(2-benzoylpiperazin-1-yl)-4-(2,4,5-t...)
Affinity DataKi:  44nMAssay Description:Inhibition of pig kidney DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Sus scrofa (pig))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50206820((R)-3-amino-1-(2-benzoyl-1,2-diazepan-1-yl)-4-(2,4...)
Affinity DataKi:  56.2nMAssay Description:Inhibition of pig kidney DPP4More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50220217(CHEMBL238138 | [3-hydroxy-3',5'-bis-trifluoromethy...)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of PTP1B after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50220217(CHEMBL238138 | [3-hydroxy-3',5'-bis-trifluoromethy...)
Affinity DataKi:  8.20E+3nMAssay Description:Inhibition of TC-PTP after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50334712((R,E)-3-(2-Fluoro-benzenesulfonyl)-thiazolidine-2-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50334712((R,E)-3-(2-Fluoro-benzenesulfonyl)-thiazolidine-2-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50334708((E)-3-[(2-Fluorophenyl)sulfonyl]-N-[5-(aminocarbon...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50334708((E)-3-[(2-Fluorophenyl)sulfonyl]-N-[5-(aminocarbon...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Korea University

Curated by ChEMBL
LigandPNGBDBM50334709(3-(3-Fluoro-benzenesulfonyl)-thiazolidine-2-carbox...)
Affinity DataIC50:  4nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50334704(3-(3,4-Dichloro-benzenesulfonyl)-thiazolidine-2-ca...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Korea University

Curated by ChEMBL
LigandPNGBDBM50334705(3-Benzenesulfonyl-thiazolidine-2-carboxylic acid(5...)
Affinity DataIC50:  6nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50334706(3-(Toluene-4-sulfonyl)-thiazolidine-2-carboxylic a...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50081724((4-{5-[1-Aza-bicyclo[2.2.2]oct-(3Z)-ylidenemethyl]...)
Affinity DataIC50: >10nMAssay Description:The compound was tested for its binding affinity against M1 human recombinant muscarinic receptor in CHO cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50334714((R)-1-(2-Fluoro-benzenesulfonyl)-pyrrolidine-2-car...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50334694(3-Benzenesulfonyl-thiazolidine-2-carboxylic acid a...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50081729(4-{5-[1-Aza-bicyclo[2.2.2]oct-(3Z)-ylidenemethyl]-...)
Affinity DataIC50: >10nMAssay Description:The compound was tested for its binding affinity against nicotinic receptor in synaptic membrane fractions from rat cerebral cortices.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50334699(3-(2-Fluoro-benzenesulfonyl)-thiazolidine-2-carbox...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50334700(3-(4-Chloro-benzenesulfonyl)-thiazolidine-2-carbox...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50334701(3-(3,4-Dichloro-benzenesulfonyl)-thiazolidine-2-ca...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50334709(3-(3-Fluoro-benzenesulfonyl)-thiazolidine-2-carbox...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50334710(3-(4-Fluoro-benzenesulfonyl)-thiazolidine-2-carbox...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50334711((S)-3-(2-Fluoro-benzenesulfonyl)-thiazolidine-2-ca...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50081733(3-(3-Methyl-isoxazol-5-ylmethylene)-1-aza-bicyclo[...)
Affinity DataIC50:  12nMAssay Description:Compound was tested for its binding affinity against nicotinic receptor in synaptic membrane fractions from rat cerebral cortices.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50334711((S)-3-(2-Fluoro-benzenesulfonyl)-thiazolidine-2-ca...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataIC50:  16nMAssay Description:Compound was tested for its binding affinity against nicotinic receptor in synaptic membrane fractions from rat cerebral cortices.More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50334707(3-(4-Methoxy-benzenesulfonyl)-thiazolidine-2-carbo...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50334698(3-(4-Fluoro-benzenesulfonyl)-thiazolidine-2-carbox...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50334695(3-(Toluene-4-sulfonyl)-thiazolidine-2-carboxylic a...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50334689(3-Benzyl-thiazolidine-2-carboxylic acid adamantan-...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

LigandPNGBDBM91658(N-aryl-4-aryl-1,3-thiazole-2-amine, 6)
Affinity DataIC50:  25nMpH: 7.4 T: 2°CAssay Description:5-LOX enzyme assay was carried out with some modifications of ferric oxidation of xylenol orange (FOX) assay, which is based on the complex formation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50309943(2-(3-Benzoyl-4-hydroxy-1,1-dioxo-1H-1lambda*6*-ben...)
Affinity DataIC50:  28nMAssay Description:Inhibition of 11beta-HSD1 in human microsomes by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50309944(2-(3-Benzoyl-4-hydroxy-1,1-dioxo-1H-1lambda*6*-ben...)
Affinity DataIC50:  30nMAssay Description:Inhibition of 11beta-HSD1 in human microsomes by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50309945(4-[2-(3-Benzoyl-4-hydroxy-1,1-dioxo-1H-1lambda*6*-...)
Affinity DataIC50:  31nMAssay Description:Inhibition of 11beta-HSD1 in human microsomes by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50309934(2-(3-Benzoyl-4-hydroxy-1,1-dioxo-1H-1lambda*6*-ben...)
Affinity DataIC50:  31nMAssay Description:Inhibition of 11beta-HSD1 in human microsomes by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

LigandPNGBDBM50312869(4-(4-(4-chlorophenyl)thiazol-2-ylamino)phenol | CH...)
Affinity DataIC50:  35nMpH: 7.4 T: 2°CAssay Description:5-LOX enzyme assay was carried out with some modifications of ferric oxidation of xylenol orange (FOX) assay, which is based on the complex formation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50334713((S)-1-(2-Fluoro-benzenesulfonyl)-pyrrolidine-2-car...)
Affinity DataIC50:  37nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50309946(4-[2-(3-Benzoyl-4-hydroxy-1,1-dioxo-1H-1lambda*6*-...)
Affinity DataIC50:  40nMAssay Description:Inhibition of 11beta-HSD1 in human microsomes by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50256618((R)-3-(4-(3-amino-4-(2,4,5-trifluorophenyl)butanoy...)
Affinity DataIC50:  46.8nMAssay Description:Inhibition of DPP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50256618((R)-3-(4-(3-amino-4-(2,4,5-trifluorophenyl)butanoy...)
Affinity DataIC50:  50nMAssay Description:Inhibition of DPP4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM11162((1R)-3-oxo-3-[3-(trifluoroethyl)-5,6-dihydro[1,2,4...)
Affinity DataIC50:  50nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50206821((R)-3-amino-1-(2-benzoylpiperazin-1-yl)-4-(2,4,5-t...)
Affinity DataIC50:  50nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50334696(3-(4-Methoxy-benzenesulfonyl)-thiazolidine-2-carbo...)
Affinity DataIC50:  55nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Korea University

Curated by ChEMBL
LigandPNGBDBM50334707(3-(4-Methoxy-benzenesulfonyl)-thiazolidine-2-carbo...)
Affinity DataIC50:  57nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

LigandPNGBDBM91673(N-aryl-4-aryl-1,3-thiazole-2-amine, 31)
Affinity DataIC50:  60nMpH: 7.4 T: 2°CAssay Description:5-LOX enzyme assay was carried out with some modifications of ferric oxidation of xylenol orange (FOX) assay, which is based on the complex formation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Rattus norvegicus (rat))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50150870(6-{2-[2-((S)-5-Cyano-pyrazolidin-1-yl)-2-oxo-ethyl...)
Affinity DataIC50:  60nMAssay Description:Inhibitory concentration against rat dipeptidyl peptidase IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

LigandPNGBDBM91665(N-aryl-4-aryl-1,3-thiazole-2-amine, 15)
Affinity DataIC50:  63nMpH: 7.4 T: 2°CAssay Description:5-LOX enzyme assay was carried out with some modifications of ferric oxidation of xylenol orange (FOX) assay, which is based on the complex formation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50334692(3-Benzoyl-thiazolidine-2-carboxylic acid adamantan...)
Affinity DataIC50:  63nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

LigandPNGBDBM91659(N-aryl-4-aryl-1,3-thiazole-2-amine, 8)
Affinity DataIC50:  65nMpH: 7.4 T: 2°CAssay Description:5-LOX enzyme assay was carried out with some modifications of ferric oxidation of xylenol orange (FOX) assay, which is based on the complex formation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50334705(3-Benzenesulfonyl-thiazolidine-2-carboxylic acid(5...)
Affinity DataIC50:  67nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50256619((R)-5-(4-(3-amino-4-(2,4,5-trifluorophenyl)butanoy...)
Affinity DataIC50:  67nMAssay Description:Inhibition of DPP4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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