Reaction Details Report a problem with these data
Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50217856
Substrate
n/a
Meas. Tech.
ChEMBL_456953 (CHEMBL924315)
EC50
840±n/a nM
Citation
Ahn, JH; Shin, MS; Jung, SH; Kim, JA; Kim, HM; Kim, SH; Kang, SK; Kim, KR; Rhee, SD; Park, SD; Lee, JM; Lee, JH; Cheon, HG; Kim, SS Synthesis and structure-activity relationship of novel indene N-oxide derivatives as potent peroxisome proliferator activated receptor gamma (PPARgamma) agonists. Bioorg Med Chem Lett 17:5239-44 (2007) [PubMed] Article
More Info.:
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Homo sapiens (Human)
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
Inhibitor
Name:
BDBM50217856
Synonyms:
CHEMBL249438 | ethyl 6-[2-(adamantan-1-yl)ethoxy]-1-(methylnitroso)-3-phenyl-1H-indene-2-carboxylate
Type:
Small organic molecule
Emp. Form.:
C31H35NO4
Mol. Mass.:
485.6139
SMILES:
CCOC(=O)c1c(-c2ccccc2)c2ccc(OCCC34CC5CC(CC(C5)C3)C4)cc2[c-]1[N+](C)=O |TLB:23:24:22.27.21:28,THB:23:22:24.25.29:28,25:24:21:27.26.28,25:26:23.24.29:21|