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Target
Insulin-like growth factor 1 receptor
Ligand
BDBM50219363
Substrate
n/a
Meas. Tech.
ChEMBL_457183 (CHEMBL941657)
IC50
152±n/a nM
Citation
 Hubbard, RD; Bamaung, NY; Palazzo, F; Zhang, Q; Kovar, P; Osterling, DJ; Hu, X; Wilsbacher, JL; Johnson, EF; Bouska, J; Wang, J; Bell, RL; Davidsen, SK; Sheppard, GS Pyrazolo[3,4-d]pyrimidines as potent inhibitors of the insulin-like growth factor receptor (IGF-IR). Bioorg Med Chem Lett 17:5406-9 (2007) [PubMed]  Article 
Target
Name:
Insulin-like growth factor 1 receptor
Synonyms:
CD_antigen=CD221 | IGF-I receptor | IGF1R | IGF1R_HUMAN | Insulin-like growth factor 1 receptor (IGF1R) | Insulin-like growth factor 1 receptor (IGFIR) | Insulin-like growth factor 1 receptor alpha chain | Insulin-like growth factor 1 receptor beta chain | Insulin-like growth factor I receptor | Insulin-like growth factor receptor (IGFR)
Type:
Protein
Mol. Mass.:
154776.79
Organism:
Homo sapiens (Human)
Description:
P08069
Residue:
1367
Sequence:
MKSGSGGGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGDLCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANILSAESSDSEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTAADTYNITDPEELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAKTGYENFIHLIIALPVAVLLIVGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENKLPEPEELDLEPENMESVPLDPSASSSSLPLPDRHSGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKNERALPLPQSSTC
  
Inhibitor
Name:
BDBM50219363
Synonyms:
3-(2-(3,5-difluorobenzyl)-1H-benzo[d]imidazol-5-yl)-1-((1r,4r)-4-morpholinocyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | CHEMBL438344
Type:
Small organic molecule
Emp. Form.:
C29H30F2N8O
Mol. Mass.:
544.5983
SMILES:
Nc1ncnc2n(nc(-c3ccc4nc(Cc5cc(F)cc(F)c5)[nH]c4c3)c12)[C@H]1CC[C@@H](CC1)N1CCOCC1 |wU:28.32,wD:31.39,(24.76,-20.51,;24.77,-22.05,;23.45,-22.82,;23.44,-24.37,;24.77,-25.14,;26.11,-24.37,;27.59,-24.85,;28.5,-23.59,;27.59,-22.34,;28.06,-20.87,;27.03,-19.74,;27.5,-18.28,;29.01,-17.95,;29.79,-16.62,;31.3,-16.94,;32.45,-15.92,;33.91,-16.4,;35.05,-15.38,;36.51,-15.86,;37.66,-14.83,;36.83,-17.37,;35.68,-18.39,;35.99,-19.9,;34.22,-17.91,;31.45,-18.48,;30.04,-19.1,;29.57,-20.56,;26.11,-22.82,;28.07,-26.31,;29.58,-26.62,;30.05,-28.1,;29.01,-29.24,;27.51,-28.91,;27.04,-27.45,;29.49,-30.71,;28.45,-31.85,;28.92,-33.31,;30.42,-33.64,;31.46,-32.5,;30.99,-31.03,)|
Structure:
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