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Target
D(2) dopamine receptor
Ligand
BDBM50221382
Substrate
n/a
Meas. Tech.
ChEMBL_449578 (CHEMBL897619)
Ki
136±n/a nM
Citation
 Sasse, BC; Mach, UR; Leppaenen, J; Calmels, T; Stark, H Hybrid approach for the design of highly affine and selective dopamine D(3) receptor ligands using privileged scaffolds of biogenic amine GPCR ligands. Bioorg Med Chem 15:7258-73 (2007) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50221382
Synonyms:
CHEMBL394189 | N-{4-[4-(diphenylmethyl)-1,4-diazepan-1-yl]butyl}-naphthalen-2-carboxamide
Type:
Small organic molecule
Emp. Form.:
C33H37N3O
Mol. Mass.:
491.6664
SMILES:
O=C(NCCCCN1CCCN(CC1)C(c1ccccc1)c1ccccc1)c1ccc2ccccc2c1
Structure:
Search PDB for entries with ligand similarity: