Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM50221369
Substrate
n/a
Meas. Tech.
ChEMBL_449579 (CHEMBL897620)
Ki
2.82±n/a nM
Citation
 Sasse, BC; Mach, UR; Leppaenen, J; Calmels, T; Stark, H Hybrid approach for the design of highly affine and selective dopamine D(3) receptor ligands using privileged scaffolds of biogenic amine GPCR ligands. Bioorg Med Chem 15:7258-73 (2007) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50221369
Synonyms:
CHEMBL394019 | N-(4-{4-[(4-chlorophenyl)phenylmethyl]piperazin-1-yl}butyl)naphthalen-2-carboxamide
Type:
Small organic molecule
Emp. Form.:
C32H34ClN3O
Mol. Mass.:
512.085
SMILES:
Clc1ccc(cc1)C(N1CCN(CCCCNC(=O)c2ccc3ccccc3c2)CC1)c1ccccc1 |w:7.34|
Structure:
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