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Target
Tyrosine-protein phosphatase non-receptor type 2
Ligand
BDBM50228008
Substrate
n/a
Meas. Tech.
ChEMBL_461677 (CHEMBL927698)
IC50
46±n/a nM
Citation
 Douty, B; Wayland, B; Ala, PJ; Bower, MJ; Pruitt, J; Bostrom, L; Wei, M; Klabe, R; Gonneville, L; Wynn, R; Burn, TC; Liu, PC; Combs, AP; Yue, EW Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolines. Bioorg Med Chem Lett 18:66-71 (2008) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 2
Synonyms:
PTN2_HUMAN | PTPN2 | PTPT | T-cell protein tyrosine phosphatase (TCPTP) | T-cell protein-tyrosine phosphatase | TC-PTP | TCPTP | Tyrosine-protein phosphatase non-receptor type 2 | Tyrosine-protein phosphatase non-receptor type 2 (TC-PTP)
Type:
Protein
Mol. Mass.:
48481.80
Organism:
Homo sapiens (Human)
Description:
P17706
Residue:
415
Sequence:
MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPAFDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKATTAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
  
Inhibitor
Name:
BDBM50228008
Synonyms:
2-[4-(2-{1-(3-fluoro-benzenesulfonylamino)-2-[3-methyl-4-(1,1,3-trioxo-1lambda6-isothiazolidin-5-yl)-phenyl]-ethyl}-3H-imidazol-4-yl)-butoxy]-6-hydroxy-benzoic acid | CHEMBL402032
Type:
Small organic molecule
Emp. Form.:
C32H33FN4O9S2
Mol. Mass.:
700.754
SMILES:
Cc1cc(CC(NS(=O)(=O)c2cccc(F)c2)c2ncc(CCCCOc3cccc(O)c3C(O)=O)[nH]2)ccc1C1CC(=O)NS1(=O)=O |w:5.5|
Structure:
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