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Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50231916
Substrate
n/a
Meas. Tech.
ChEMBL_462097 (CHEMBL944929)
Ki
5±n/a nM
Citation
 Yoon, T; De Lombaert, S; Brodbeck, R; Gulianello, M; Chandrasekhar, J; Horvath, RF; Ge, P; Kershaw, MT; Krause, JE; Kehne, J; Hoffman, D; Doller, D; Hodgetts, KJ The design, synthesis and structure-activity relationships of 1-aryl-4-aminoalkylisoquinolines: a novel series of CRF-1 receptor antagonists. Bioorg Med Chem Lett 18:891-6 (2008) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50231916
Synonyms:
CHEMBL404351 | N-(cyclopropylmethyl)-1-(2-methoxy-4,6-dimethylphenyl)-3-methyl-N-propylisoquinolin-4-amine
Type:
Small organic molecule
Emp. Form.:
C26H32N2O
Mol. Mass.:
388.5451
SMILES:
CCCN(CC1CC1)c1c(C)nc(-c2c(C)cc(C)cc2OC)c2ccccc12 |(14.99,5.95,;16.33,5.19,;16.34,3.65,;17.67,2.88,;19,3.66,;19,5.2,;19.77,6.53,;18.23,6.52,;17.68,1.34,;16.36,.57,;15.02,1.34,;16.35,-.97,;17.68,-1.74,;17.69,-3.28,;16.35,-4.05,;15.02,-3.28,;16.35,-5.59,;17.69,-6.36,;17.69,-7.9,;19.03,-5.58,;19.02,-4.04,;20.35,-3.27,;21.69,-4.03,;19.02,-.96,;20.34,-1.73,;21.7,-.96,;21.69,.59,;20.35,1.35,;19.02,.58,)|
Structure:
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