Reaction Details Report a problem with these data
Target
C-X-C chemokine receptor type 1
Ligand
BDBM50269197
Substrate
n/a
Meas. Tech.
ChEMBL_528388 (CHEMBL974176)
IC50
5500±n/a nM
Citation
 de Almeida Leone, P; Redburn, J; Hooper, JN; Quinn, RJ Polyoxygenated dysidea sterols that inhibit the binding of [I125] IL-8 to the human recombinant IL-8 receptor type A. J Nat Prod 63:694-7 (2000) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 1
Synonyms:
C-X-C chemokine receptor type 1 (CXCR-1) | C-X-C chemokine receptor type 1 (CXCR1) | CMKAR1 | CXCR1 | CXCR1_HUMAN | IL8RA | Interleukin-8 receptor A | Interleukin-8 receptors, CXCR1/CXCR2
Type:
Enzyme
Mol. Mass.:
39803.83
Organism:
Homo sapiens (Human)
Description:
P25024
Residue:
350
Sequence:
MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
  
Inhibitor
Name:
BDBM50269197
Synonyms:
CHEMBL451438 | cholest-8-ene-3beta,5alpha,6alpha,7alpha,10alpha-pentol 3,6,7-triacetate
Type:
Small organic molecule
Emp. Form.:
C33H52O8
Mol. Mass.:
576.7612
SMILES:
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2C3=C([C@H](O)C[C@]12C)[C@@]1(C)CC[C@@H](C[C@]1(O)[C@@H](OC(C)=O)[C@H]3OC(C)=O)OC(C)=O |r,c:12|
Structure:
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