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Target
Sodium/hydrogen exchanger
Ligand
BDBM50270005
Substrate
n/a
Meas. Tech.
ChEMBL_506147 (CHEMBL938726)
IC50
8700±n/a nM
Citation
 Pedersen, SF; King, SA; Nygaard, EB; Rigor, RR; Cala, PM NHE1 inhibition by amiloride- and benzoylguanidine-type compounds. Inhibitor binding loci deduced from chimeras of NHE1 homologues with endogenous differences in inhibitor sensitivity. J Biol Chem 282:19716-27 (2007) [PubMed]  Article 
Target
Name:
Sodium/hydrogen exchanger
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
90748.00
Organism:
Amphiuma tridactylum
Description:
ChEMBL_506147
Residue:
813
Sequence:
MFQMWKRMACDCLGYPFRGIISPLGSICFFGAFLLFILPIGVAAFKSEAMLATEPSRSRILDDSPGITPAPTLTAHPTTNTSGNNSAGGHGKGHKVFPVLGFDYLRVRIPFEISLWILLASLMKLGFHVIPTVSNVVPESCLLIVVGLLVGGLIKGVGETPPVLHSDTFFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVLGTLWNTFCIGSLLFAVCQISGTSLNGVGLLANLLFGAIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFGTFDQVTFKDIFLGFLSFFVVALGGVFVGVVYGIVAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGPHEWNWTFVMSTLLLCLIARVLGVLGLTSVINRFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDHHHFPKRNMFLTAIITVIFFTVFVQGMTIRPLVELLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCLIAGERSTEPQLIAFYHKMELKQAIELVESGGLGRIPSAVSTVSMQNIQPKAKPTDRFIPALSKVKEEEIRKILRTNLQKTRQRLRSYNRHTLVADPYEEAWNQMLLRRQKAHQLEQRMNNYLTVPAHKMDSPTMTRARVGSDPMAYEPKANIRDLPTITIDPASPESVDIVNEEKKSLPTEEEEEEEEGIVMTAKEPPSPGTDDVFTPGAGDSPNNQRLMRCLSDPGPQPEPEEQDPFIKKEK
  
Inhibitor
Name:
BDBM50270005
Synonyms:
5'-(N-ethyl-N-isopropyl)amiloride | CHEMBL1909809 | CHEMBL517986 | cid_1795
Type:
Small organic molecule
Emp. Form.:
C11H18ClN7O
Mol. Mass.:
299.76
SMILES:
CCN(C(C)C)c1nc(N)c(nc1Cl)C(=O)NC(N)=N
Structure:
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