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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50016574
Substrate
n/a
Meas. Tech.
ChEMBL_529877 (CHEMBL968427)
IC50
79000±n/a nM
Citation
 Alexiou, P; Nicolaou, I; Stefek, M; Kristl, A; Demopoulos, VJ Design and synthesis of N-(3,5-difluoro-4-hydroxyphenyl)benzenesulfonamides as aldose reductase inhibitors. Bioorg Med Chem 16:3926-32 (2008) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:
PROTEIN
Mol. Mass.:
35797.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1512484
Residue:
316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
  
Inhibitor
Name:
BDBM50016574
Synonyms:
(4-Nitro-benzenesulfonylamino)-acetic acid | 2-(4-nitrophenylsulfonamido)acetic acid | CHEMBL288404
Type:
Small organic molecule
Emp. Form.:
C8H8N2O6S
Mol. Mass.:
260.224
SMILES:
OC(=O)CNS(=O)(=O)c1ccc(cc1)[N+]([O-])=O
Structure:
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