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Target
Nuclear receptor subfamily 1 group I member 2
Ligand
BDBM50251048
Substrate
n/a
Meas. Tech.
ChEMBL_529970 (CHEMBL975041)
EC50
20±n/a nM
Citation
 Benod, C; Subra, G; Nahoum, V; Mallavialle, A; Guichou, JF; Milhau, J; Roblés, S; Bourguet, W; Pascussi, JM; Balaguer, P; Chavanieu, A N-1H-benzimidazol-5-ylbenzenesulfonamide derivatives as potent hPXR agonists. Bioorg Med Chem 16:3537-49 (2008) [PubMed]  Article 
Target
Name:
Nuclear receptor subfamily 1 group I member 2
Synonyms:
NR1I2 | NR1I2_HUMAN | Orphan nuclear receptor PAR1 | Orphan nuclear receptor PXR | PXR | Pregnane X receptor | SXR | Steroid and xenobiotic receptor | nuclear receptor subfamily 1 group I member 2 isoform 1
Type:
Nuclear receptor
Mol. Mass.:
49774.77
Organism:
Homo sapiens (Human)
Description:
O75469
Residue:
434
Sequence:
MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS
  
Inhibitor
Name:
BDBM50251048
Synonyms:
CHEMBL457270 | N-(1-benzyl-1H-benzo[d]imidazol-5-yl)naphthalene-1-sulfonamide
Type:
Small organic molecule
Emp. Form.:
C24H19N3O2S
Mol. Mass.:
413.492
SMILES:
O=S(=O)(Nc1ccc2n(Cc3ccccc3)cnc2c1)c1cccc2ccccc12
Structure:
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