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Target
Delta-type opioid receptor
Ligand
BDBM50239754
Substrate
n/a
Meas. Tech.
ChEMBL_556070 (CHEMBL953423)
IC50
>1000±n/a nM
Citation
 Okamoto, O; Kobayashi, K; Kawamoto, H; Ito, S; Yoshizumi, T; Yamamoto, I; Hashimoto, M; Shimizu, A; Takahashi, H; Ishii, Y; Ozaki, S; Ohta, H Novel ORL1-selective antagonists with oral bioavailability and brain penetrability. Bioorg Med Chem Lett 18:3282-5 (2008) [PubMed]  Article 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50239754
Synonyms:
2-(4-(2-(tert-butylthio)-6-chloro-3H-benzo[d]imidazol-5-yl)piperazin-1-yl)ethanol | CHEMBL259185
Type:
Small organic molecule
Emp. Form.:
C17H25ClN4OS
Mol. Mass.:
368.925
SMILES:
CC(C)(C)Sc1nc2cc(Cl)c(cc2[nH]1)N1CCN(CCO)CC1
Structure:
Search PDB for entries with ligand similarity: