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Target
Adenosine receptor A3
Ligand
BDBM50271498
Substrate
n/a
Meas. Tech.
ChEMBL_556454 (CHEMBL955671)
Ki
387±n/a nM
Citation
 Colotta, V; Catarzi, D; Varano, F; Lenzi, O; Filacchioni, G; Martini, C; Trincavelli, L; Ciampi, O; Traini, C; Pugliese, AM; Pedata, F; Morizzo, E; Moro, S Synthesis, ligand-receptor modeling studies and pharmacological evaluation of novel 4-modified-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent and selective human A3 adenosine receptor antagonists. Bioorg Med Chem 16:6086-102 (2008) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50271498
Synonyms:
1,2-Dihydro-4-bismethanesulfonylamino-2-(4-methoxyphenyl)-1,2,4-triazolo[4,3-a]quinoxalin-1-one | CHEMBL520152
Type:
Small organic molecule
Emp. Form.:
C18H17N5O6S2
Mol. Mass.:
463.487
SMILES:
COc1ccc(cc1)-n1nc2c(nc3ccccc3n2c1=O)N(S(C)(=O)=O)S(C)(=O)=O
Structure:
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