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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM50240093
Substrate
n/a
Meas. Tech.
ChEMBL_556506 (CHEMBL956501)
IC50
216±n/a nM
Citation
 Buckley, GM; Ceska, TA; Fraser, JL; Gowers, L; Groom, CR; Higueruelo, AP; Jenkins, K; Mack, SR; Morgan, T; Parry, DM; Pitt, WR; Rausch, O; Richard, MD; Sabin, V IRAK-4 inhibitors. Part II: a structure-based assessment of imidazo[1,2-a]pyridine binding. Bioorg Med Chem Lett 18:3291-5 (2008) [PubMed]  Article 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM50240093
Synonyms:
4-(H-imidazo[1,2-a]pyridin-3-yl)-N-(piperidin-4-yl)pyrimidin-2-amine | CHEMBL255098
Type:
Small organic molecule
Emp. Form.:
C16H18N6
Mol. Mass.:
294.3543
SMILES:
C1CC(CCN1)Nc1nccc(n1)-c1cnc2ccccn12
Structure:
Search PDB for entries with ligand similarity: