Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50270535
Substrate
n/a
Meas. Tech.
ChEMBL_552750 (CHEMBL954028)
IC50
56±n/a nM
Citation
 Imaeda, Y; Kuroita, T; Sakamoto, H; Kawamoto, T; Tobisu, M; Konishi, N; Hiroe, K; Kawamura, M; Tanaka, T; Kubo, K Discovery of imidazo[1,5-c]imidazol-3-ones: weakly basic, orally active factor Xa inhibitors. J Med Chem 51:3422-36 (2008) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50270535
Synonyms:
1-{3-[(6-Chloronaphthalen-2-yl)sulfonyl]propanoyl}-4-(1-methyl-1H-imidazol-2-yl)piperidine | CHEMBL477279
Type:
Small organic molecule
Emp. Form.:
C22H24ClN3O3S
Mol. Mass.:
445.962
SMILES:
Cn1ccnc1C1CCN(CC1)C(=O)CCS(=O)(=O)c1ccc2cc(Cl)ccc2c1
Structure:
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