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Target
Substance-P receptor
Ligand
BDBM50243357
Substrate
n/a
Meas. Tech.
ChEMBL_491691 (CHEMBL949546)
IC50
542±n/a nM
Citation
 Cappelli, A; Giuliani, G; Anzini, M; Riitano, D; Giorgi, G; Vomero, S Design, synthesis, and structure-affinity relationship studies in NK1 receptor ligands based on azole-fused quinolinecarboxamide moieties. Bioorg Med Chem 16:6850-9 (2008) [PubMed]  Article 
Target
Name:
Substance-P receptor
Synonyms:
NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46254.43
Organism:
Homo sapiens (Human)
Description:
P25103
Residue:
407
Sequence:
MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
  
Inhibitor
Name:
BDBM50243357
Synonyms:
CHEMBL453314 | N-[3,5-Bis(trifluoromethyl)benzyl]-5-phenyl[1,2,4]triazolo[4,3-a]quinoline-4-carboxamide
Type:
Small organic molecule
Emp. Form.:
C26H16F6N4O
Mol. Mass.:
514.4219
SMILES:
FC(F)(F)c1cc(CNC(=O)c2c(-c3ccccc3)c3ccccc3n3cnnc23)cc(c1)C(F)(F)F
Structure:
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