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Target
Tryptophan 5-hydroxylase 1
Ligand
BDBM50243022
Substrate
n/a
Meas. Tech.
ChEMBL_487489 (CHEMBL1016551)
EC50
1700±n/a nM
Citation
 Shi, ZC; Devasagayaraj, A; Gu, K; Jin, H; Marinelli, B; Samala, L; Scott, S; Stouch, T; Tunoori, A; Wang, Y; Zang, Y; Zhang, C; Kimball, SD; Main, AJ; Sun, W; Yang, Q; Nouraldeen, A; Yu, XQ; Buxton, E; Patel, S; Nguyen, N; Swaffield, J; Powell, DR; Wilson, A; Liu, Q Modulation of peripheral serotonin levels by novel tryptophan hydroxylase inhibitors for the potential treatment of functional gastrointestinal disorders. J Med Chem 51:3684-7 (2008) [PubMed]  Article 
Target
Name:
Tryptophan 5-hydroxylase 1
Synonyms:
TPH1_RAT | Tph | Tph1 | Tryptophan 5-monooxygenase 1
Type:
PROTEIN
Mol. Mass.:
51069.51
Organism:
Rattus norvegicus
Description:
ChEMBL_1361815
Residue:
444
Sequence:
MIEDNKENKDHSSERGRVTLIFSLKNEVGGLIKALKIFQENHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFPLLKSHTTVLSVDSPDQLPEKEDVMETVPWFPKKISDLDFCANRVLLYGSELDADHPGFKDNVYRRRRKYFAELAMNYKHGDPIPKIEFTEEEIKTWGTIFRELNKLYPTHACREYLRNLPLLSKYCGYREDNVPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEETVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELRHALSGHAKVKPFDPKVACKQECLITSFQDVYFVSESFEDAKEKMREFAKTVKRPFGVKYNPYTQSIQVLRDSKSITSAMNELRHDLDVVNDALARVSRWPSV
  
Inhibitor
Name:
BDBM50243022
Synonyms:
(S)-2-amino-3-(4-(2-amino-6-((R)-1-(naphthalen-2-yl)ethylamino)pyrimidin-4-yl)phenyl)propanoic acid | CHEMBL469480
Type:
Small organic molecule
Emp. Form.:
C25H25N5O2
Mol. Mass.:
427.4983
SMILES:
C[C@@H](Nc1cc(nc(N)n1)-c1ccc(C[C@H](N)C(O)=O)cc1)c1ccc2ccccc2c1 |r|
Structure:
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