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Target
Histone deacetylase 1
Ligand
BDBM50251899
Substrate
n/a
Meas. Tech.
ChEMBL_491716 (CHEMBL949571)
IC50
1670±n/a nM
Citation
 Dehmel, F; Weinbrenner, S; Julius, H; Ciossek, T; Maier, T; Stengel, T; Fettis, K; Burkhardt, C; Wieland, H; Beckers, T Trithiocarbonates as a novel class of HDAC inhibitors: SAR studies, isoenzyme selectivity, and pharmacological profiles. J Med Chem 51:3985-4001 (2008) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50251899
Synonyms:
CHEMBL481922 | Ethyl 2-oxo-2-(3-Phenylcarbamoyl-phenyl)-ethyl Trithiocarbonate
Type:
Small organic molecule
Emp. Form.:
C18H17NO2S3
Mol. Mass.:
375.528
SMILES:
CCSC(=S)SCC(=O)c1cccc(c1)C(=O)Nc1ccccc1
Structure:
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