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Found 685 with Last Name = 'beckers' and Initial = 't'
TargetHistone deacetylase 6(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50252005(2-(3-Benzoylamino-phenyl)-2-oxoethyl ethyl trithio...)
Affinity DataKi:  110nMAssay Description:Inhibition of recombinant HDAC6 (unknown origin) expressed in HEK293 cells using variable substrate concentration by Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50252371(CHEMBL520279 | Ethyl 2-oxo-2-[1-(phenyl-sulfonyl)-...)
Affinity DataKi:  140nMAssay Description:Inhibition of recombinant HDAC6 (unknown origin) expressed in HEK293 cells using variable substrate concentration by Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50252319(CHEMBL479602 | Ethyl 2-oxo-2-{5-[(2-Phenoxy-ethylc...)
Affinity DataKi:  460nMAssay Description:Inhibition of recombinant HDAC1 (unknown origin) expressed in HEK293 cells using variable substrate concentration by Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50217137(CHEMBL388710 | Ethyl 2-(4-Methylphenyl)-2-oxoethyl...)
Affinity DataKi:  7.00E+3nMAssay Description:Inhibition of HDAC1 in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50217137(CHEMBL388710 | Ethyl 2-(4-Methylphenyl)-2-oxoethyl...)
Affinity DataKi:  7.00E+3nMAssay Description:Inhibition of recombinant HDAC1 (unknown origin) expressed in HEK293 cells using variable substrate concentration by Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332490(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)qu...)
Affinity DataIC50:  2nMAssay Description:Inhibition of HER2 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332493(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)qu...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of EGFR by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332483(3-{5-[4-(3-Chloro-4-(3-fluorobenzyloxy)phenylamino...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of EGFR by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332485(CHEMBL1630112 | N-(2-aminophenyl)-5-(4-(3-chloro-4...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of EGFR by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of EGFR by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332484(CHEMBL1630111 | N-(2-aminophenyl)-5-(4-(3-chloro-4...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of EGFR by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM145937(US8957064, 57.0)
Affinity DataIC50:  3nMpH: 7.5Assay Description:Akt2 inhibitory activity of compounds of the present invention was quantified employing the Akt2 TR-FRET assay as described in the following paragrap...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM145934(US8957064, 54.0)
Affinity DataIC50:  3nMpH: 7.5Assay Description:Akt1 inhibitory activity of compounds of the present invention may be quantified0 employing the Akt1 TR-FRET assay as described in the following para...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of EGFR using poly(Glu,Tyr)4:1 as substrate and [gamma33P]ATP after 60 mins by scintillation countingMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332491((E)-3-(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of HER2 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332493(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)qu...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of HER2 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332490(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)qu...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of EGFR by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM145889(US8957064, 26.0)
Affinity DataIC50:  4nMpH: 7.5Assay Description:Akt2 inhibitory activity of compounds of the present invention was quantified employing the Akt2 TR-FRET assay as described in the following paragrap...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM145953(US8957064, 71.0)
Affinity DataIC50:  4nMpH: 7.5Assay Description:Akt2 inhibitory activity of compounds of the present invention was quantified employing the Akt2 TR-FRET assay as described in the following paragrap...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM145958(US8957064, 72.4)
Affinity DataIC50:  4nMpH: 7.5Assay Description:Akt2 inhibitory activity of compounds of the present invention was quantified employing the Akt2 TR-FRET assay as described in the following paragrap...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM145872(US8957064, 10.0 | US8957064, 36.0)
Affinity DataIC50:  4nMpH: 7.5Assay Description:Akt1 inhibitory activity of compounds of the present invention may be quantified0 employing the Akt1 TR-FRET assay as described in the following para...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM145889(US8957064, 26.0)
Affinity DataIC50:  4nMpH: 7.5Assay Description:Akt1 inhibitory activity of compounds of the present invention may be quantified0 employing the Akt1 TR-FRET assay as described in the following para...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332483(3-{5-[4-(3-Chloro-4-(3-fluorobenzyloxy)phenylamino...)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of HER2 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of HER2 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332489(CHEMBL1630116 | N-(2-aminophenyl)-3-(4-(4-(3-chlor...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of HER2 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332491((E)-3-(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of EGFR by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332485(CHEMBL1630112 | N-(2-aminophenyl)-5-(4-(3-chloro-4...)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of HER2 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM145920(US8957064, 48.1)
Affinity DataIC50:  5nMpH: 7.5Assay Description:Akt1 inhibitory activity of compounds of the present invention may be quantified0 employing the Akt1 TR-FRET assay as described in the following para...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM145954(US8957064, 72.0)
Affinity DataIC50:  5nMpH: 7.5Assay Description:Akt1 inhibitory activity of compounds of the present invention may be quantified0 employing the Akt1 TR-FRET assay as described in the following para...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM145952(US8957064, 70.0)
Affinity DataIC50:  5nMpH: 7.5Assay Description:Akt2 inhibitory activity of compounds of the present invention was quantified employing the Akt2 TR-FRET assay as described in the following paragrap...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM145905(US8957064, 42.0)
Affinity DataIC50:  5nMpH: 7.5Assay Description:Akt1 inhibitory activity of compounds of the present invention may be quantified0 employing the Akt1 TR-FRET assay as described in the following para...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM145953(US8957064, 71.0)
Affinity DataIC50:  5nMpH: 7.5Assay Description:Akt1 inhibitory activity of compounds of the present invention may be quantified0 employing the Akt1 TR-FRET assay as described in the following para...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM145958(US8957064, 72.4)
Affinity DataIC50:  5nMpH: 7.5Assay Description:Akt1 inhibitory activity of compounds of the present invention may be quantified0 employing the Akt1 TR-FRET assay as described in the following para...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50359993(CHEMBL1928291)
Affinity DataIC50:  5.54nMAssay Description:Inhibition of EGFR using poly(Glu,Tyr)4:1 as substrate and [gamma33P]ATP after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332484(CHEMBL1630111 | N-(2-aminophenyl)-5-(4-(3-chloro-4...)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of HER2 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50359997(CHEMBL1928312)
Affinity DataIC50:  5.93nMAssay Description:Inhibition of EGFR using poly(Glu,Tyr)4:1 as substrate and [gamma33P]ATP after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM145867(US8957064, 5.0)
Affinity DataIC50:  6nMpH: 7.5Assay Description:Akt1 inhibitory activity of compounds of the present invention may be quantified0 employing the Akt1 TR-FRET assay as described in the following para...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM145935(US8957064, 55.0)
Affinity DataIC50:  6nMpH: 7.5Assay Description:Akt1 inhibitory activity of compounds of the present invention may be quantified0 employing the Akt1 TR-FRET assay as described in the following para...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM145937(US8957064, 57.0)
Affinity DataIC50:  6nMpH: 7.5Assay Description:Akt1 inhibitory activity of compounds of the present invention may be quantified0 employing the Akt1 TR-FRET assay as described in the following para...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM145932(US8957064, 53.0)
Affinity DataIC50:  7nMpH: 7.5Assay Description:Akt2 inhibitory activity of compounds of the present invention was quantified employing the Akt2 TR-FRET assay as described in the following paragrap...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM145888(US8957064, 25.0)
Affinity DataIC50:  7nMpH: 7.5Assay Description:Akt1 inhibitory activity of compounds of the present invention may be quantified0 employing the Akt1 TR-FRET assay as described in the following para...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM145895(US8957064, 32.0)
Affinity DataIC50:  7nMpH: 7.5Assay Description:Akt1 inhibitory activity of compounds of the present invention may be quantified0 employing the Akt1 TR-FRET assay as described in the following para...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM145909(US8957064, 44.0)
Affinity DataIC50:  7nMpH: 7.5Assay Description:Akt1 inhibitory activity of compounds of the present invention may be quantified0 employing the Akt1 TR-FRET assay as described in the following para...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM145919(US8957064, 48.0)
Affinity DataIC50:  7nMpH: 7.5Assay Description:Akt1 inhibitory activity of compounds of the present invention may be quantified0 employing the Akt1 TR-FRET assay as described in the following para...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM145952(US8957064, 70.0)
Affinity DataIC50:  7nMpH: 7.5Assay Description:Akt1 inhibitory activity of compounds of the present invention may be quantified0 employing the Akt1 TR-FRET assay as described in the following para...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM145955(US8957064, 72.1)
Affinity DataIC50:  7nMpH: 7.5Assay Description:Akt1 inhibitory activity of compounds of the present invention may be quantified0 employing the Akt1 TR-FRET assay as described in the following para...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM145943(US8957064, 63.1)
Affinity DataIC50:  8nMpH: 7.5Assay Description:Akt1 inhibitory activity of compounds of the present invention may be quantified0 employing the Akt1 TR-FRET assay as described in the following para...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM145910(US8957064, 44.1)
Affinity DataIC50:  8nMpH: 7.5Assay Description:Akt2 inhibitory activity of compounds of the present invention was quantified employing the Akt2 TR-FRET assay as described in the following paragrap...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM145930(US8957064, 52.1)
Affinity DataIC50:  8nMpH: 7.5Assay Description:Akt1 inhibitory activity of compounds of the present invention may be quantified0 employing the Akt1 TR-FRET assay as described in the following para...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332486(CHEMBL1630113 | N-(2-aminophenyl)-3-(5-(4-(3-chlor...)
Affinity DataIC50:  8.70nMAssay Description:Inhibition of HER2 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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