Reaction Details Report a problem with these data
Target
Bcl2-associated agonist of cell death
Ligand
BDBM50262597
Substrate
n/a
Meas. Tech.
ChEMBL_489247 (CHEMBL989994)
Kd
70000±n/a nM
Citation
 Prakesch, M; Denisov, AY; Naim, M; Gehring, K; Arya, P The discovery of small molecule chemical probes of Bcl-X(L) and Mcl-1. Bioorg Med Chem 16:7443-9 (2008) [PubMed]  Article 
Target
Name:
Bcl2-associated agonist of cell death
Synonyms:
BAD_MOUSE | Bad | Bbc6 | GST fusion protein of Bcl2 antagonist of cell death | GST-BAD
Type:
Other Protein Type
Mol. Mass.:
22084.58
Organism:
Mus musculus (mouse)
Description:
n/a
Residue:
204
Sequence:
MGTPKQPSLAPAHALGLRKSDPGIRSLGSDAGGRRWRPAAQSMFQIPEFEPSEQEDASATDRGLGPSLTEDQPGPYLAPGLLGSNIHQQGRAATNSHHGGAGAMETRSRHSSYPAGTEEDEGMEEELSPFRGRSRSAPPNLWAAQRYGRELRRMSDEFEGSFKGLPRPKSAGTATQMRQSAGWTRIIQSWWDRNLGKGGSTPSQ
  
Inhibitor
Name:
BDBM50262597
Synonyms:
CHEMBL453437 | [(2S,3R,4S)-1-(Biphenyl-4-carbonyl)-4-[(biphenyl-4-carbonyl)-amino]-3-hydroxy-6-(2-methoxy-ethoxymethoxy)-1,2,3,4-tetrahydro-quinolin-2-yl]-acetic acid
Type:
Small organic molecule
Emp. Form.:
C41H38N2O8
Mol. Mass.:
686.749
SMILES:
COCCOCOc1ccc2N([C@@H](CC(O)=O)[C@H](O)[C@@H](NC(=O)c3ccc(cc3)-c3ccccc3)c2c1)C(=O)c1ccc(cc1)-c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: