Reaction Details Report a problem with these data
Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM50273036
Substrate
n/a
Meas. Tech.
ChEMBL_513688 (CHEMBL974538)
IC50
14±n/a nM
Citation
 Hebeisen, P; Kuhn, B; Kohler, P; Gubler, M; Huber, W; Kitas, E; Schott, B; Benz, J; Joseph, C; Ruf, A Allosteric FBPase inhibitors gain 10(5) times in potency when simultaneously binding two neighboring AMP sites. Bioorg Med Chem Lett 18:4708-12 (2008) [PubMed]  Article 
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | F16P1_HUMAN | FBP | FBP1 | FBPase 1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 | Fructose-1,6-bisphosphatase 1 (FBPase)
Type:
Protein
Mol. Mass.:
36843.58
Organism:
Homo sapiens (Human)
Description:
Liver FBPase (P09467)
Residue:
338
Sequence:
MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
  
Inhibitor
Name:
BDBM50273036
Synonyms:
1-[(3-chlorobenzene)sulfonyl]-3-[(3E)-6-({[(3-chlorobenzene)sulfonyl]carbamoyl}amino)hex-3-en-1-yl]urea | CHEMBL456564
Type:
Small organic molecule
Emp. Form.:
C20H22Cl2N4O6S2
Mol. Mass.:
549.448
SMILES:
Clc1cccc(c1)S(=O)(=O)NC(=O)NCC\C=C\CCNC(=O)NS(=O)(=O)c1cccc(Cl)c1
Structure:
Search PDB for entries with ligand similarity: