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Target
Estrogen receptor beta
Ligand
BDBM50264121
Substrate
n/a
Meas. Tech.
ChEMBL_535113 (CHEMBL983676)
Ki
16±n/a nM
Citation
 Fang, J; Akwabi-Ameyaw, A; Britton, JE; Katamreddy, SR; Navas, F; Miller, AB; Williams, SP; Gray, DW; Orband-Miller, LA; Shearin, J; Heyer, D Synthesis of 3-alkyl naphthalenes as novel estrogen receptor ligands. Bioorg Med Chem Lett 18:5075-7 (2008) [PubMed]  Article 
Target
Name:
Estrogen receptor beta
Synonyms:
ER-beta | ESR2 | ESR2_HUMAN | ESTRB | Estradiol receptor beta (ERβ) | Estrogen receptor | Estrogen receptor (ER beta) | Estrogen receptor beta | Estrogen receptor beta (ER beta) | Estrogen receptor beta (ER) | NR3A2 | Nuclear receptor subfamily 3 group A member 2 | estrogen beta
Type:
Protein
Mol. Mass.:
59238.43
Organism:
Homo sapiens (Human)
Description:
Q92731
Residue:
530
Sequence:
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
  
Inhibitor
Name:
BDBM50264121
Synonyms:
3-(4-(3-cyclopropyl-6-hydroxy-2-phenylnaphthalen-1-yloxy)phenyl)acrylic acid | CHEMBL490197
Type:
Small organic molecule
Emp. Form.:
C28H22O4
Mol. Mass.:
422.4719
SMILES:
OC(=O)\C=C\c1ccc(Oc2c(-c3ccccc3)c(cc3cc(O)ccc23)C2CC2)cc1
Structure:
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