Target
Monoglyceride lipase
Ligand
BDBM50247052
Substrate
n/a
Meas. Tech.
ChEMBL_557786 (CHEMBL953295)
IC50
0.31±n/a nM
Citation
 Nomura, DKHudak, CSWard, AMBurston, JJIssa, RSFisher, KJAbood, MEWiley, JLLichtman, AHCasida, JE Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels. Bioorg Med Chem Lett 18:5875-8 (2008) [PubMed]  Article 
Target
Name:
Monoglyceride lipase
Synonyms:
MAG lipase | MGLL_MOUSE | Mgll | Monoacylglycerol lipase | Monoglyceride Lipase (MGL)
Type:
Hydrolase
Mol. Mass.:
33391.67
Organism:
Mus musculus (mouse)
Description:
Assays were using membranes of recombinant MAG Lipase transiently transfected in COS-7 cells.
Residue:
303
Sequence:
MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDELAHMLKGLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDVLQHVDTIQKDYPDVPIFLLGHSMGGAISILVAAERPTYFSGMVLISPLVLANPESASTLKVLAAKLLNFVLPNMTLGRIDSSVLSRNKSEVDLYNSDPLVCRAGLKVCFGIQLLNAVARVERAMPRLTLPFLLLQGSADRLCDSKGAYLLMESSRSQDKTLKMYEGAYHVLHRELPEVTNSVLHEVNSWVSHRIAAAGAGCPP
  
Inhibitor
Name:
BDBM50247052
Synonyms:
2-Nonylsulfanyl-4H-benzo[1,3,2]dioxaphosphinine 2-oxide | CHEMBL450965
Type:
Small organic molecule
Emp. Form.:
C16H25O3PS
Mol. Mass.:
328.407
SMILES:
CCCCCCCCCSP1(=O)OCc2ccccc2O1
Structure:
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