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Target
Serine/threonine-protein kinase PLK1
Ligand
BDBM50263645
Substrate
n/a
Meas. Tech.
ChEMBL_535435 (CHEMBL985261)
IC50
345±n/a nM
Citation
 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Pharmacophore modeling and virtual screening for designing potential PLK1 inhibitors. Bioorg Med Chem Lett 18:4972-7 (2008) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase PLK1
Synonyms:
PLK | PLK-1 | PLK1 | PLK1_HUMAN | Polo-like kinase 1 (PlK1) | Polo-like kinase 1 (Plk-1) | STPK13 | Serine/threonine-protein kinase (PLK1) | Serine/threonine-protein kinase 13 | polo-like kinase
Type:
Serine/threonine-protein kinase
Mol. Mass.:
68277.16
Organism:
Human
Description:
P53350
Residue:
603
Sequence:
MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS
  
Inhibitor
Name:
BDBM50263645
Synonyms:
3-((2-(1-cyano-2-(ethylamino)-2-oxoethylidene)-3-ethyl-4-oxothiazolidin-5-ylidene)methylamino)-N-(3-(pyrrolidin-1-yl)propyl)benzamide | CHEMBL475946
Type:
Small organic molecule
Emp. Form.:
C25H32N6O3S
Mol. Mass.:
496.625
SMILES:
CCNC(=O)C(\C#N)=c1/s\c(=C\Nc2cccc(c2)C(=O)NCCCN2CCCC2)c(=O)n1CC
Structure:
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