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Target
B-cell receptor CD22
Ligand
BDBM50274284
Substrate
n/a
Meas. Tech.
ChEMBL_537287 (CHEMBL985383)
IC50
40850±n/a nM
Citation
 Abdu-Allah, HH; Tamanaka, T; Yu, J; Zhuoyuan, L; Sadagopan, M; Adachi, T; Tsubata, T; Kelm, S; Ishida, H; Kiso, M Design, synthesis, and structure-affinity relationships of novel series of sialosides as CD22-specific inhibitors. J Med Chem 51:6665-81 (2008) [PubMed]  Article 
Target
Name:
B-cell receptor CD22
Synonyms:
CD22 | CD22_HUMAN | SIGLEC2
Type:
PROTEIN
Mol. Mass.:
95348.60
Organism:
Homo sapiens (Human)
Description:
ChEMBL_727026
Residue:
847
Sequence:
MHLLGPWLLLLVLEYLAFSDSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLESFILFHNPEYNKNTSKFDGTRLYESTKDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGVLKIQNVGWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPETIGRRVAVGLGSCLAILILAICGLKLQRRWKRTQSQQGLQENSSGQSFFVRNKKVRRAPLSEGPHSLGCYNPMMEDGISYTTLRFPEMNIPRTGDAESSEMQRPPPDCDDTVTYSALHKRQVGDYENVIPDFPEDEGIHYSELIQFGVGERPQAQENVDYVILKH
  
Inhibitor
Name:
BDBM50274284
Synonyms:
CHEMBL451579 | p-Methoxyphenyl (3,5,9-trideoxy-5-glycolamido-9-hexanamido-D-glycero-alpha-D-galacto-2-nonulopyranosylonic acid)-(2->6)-beta-D-galactopyranoside
Type:
Small organic molecule
Emp. Form.:
C30H46N2O16
Mol. Mass.:
690.69
SMILES:
CCCCCC(=O)NC[C@@H](O)[C@@H](O)[C@@H]1O[C@@](C[C@H](O)[C@H]1NC(=O)CO)(OC[C@H]1O[C@@H](Oc2ccc(OC)cc2)[C@H](O)[C@@H](O)[C@H]1O)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: