Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM50256703
Substrate
n/a
Meas. Tech.
ChEMBL_519597 (CHEMBL943672)
EC50
0.1±n/a nM
Citation
 Bharate, SB; Rodge, A; Joshi, RK; Kaur, J; Srinivasan, S; Kumar, SS; Kulkarni-Almeida, A; Balachandran, S; Balakrishnan, A; Vishwakarma, RA Discovery of diacylphloroglucinols as a new class of GPR40 (FFAR1) agonists. Bioorg Med Chem Lett 18:6357-61 (2008) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM50256703
Synonyms:
(1R,1aS,6aR)-4-(2-Chloro-4-trifluoromethyl-phenoxy)-1a,6a-dihydro-1H-6-oxa-cyclopropa[a]indene-1-carboxylic acid | CHEMBL475027
Type:
Small organic molecule
Emp. Form.:
C17H10ClF3O4
Mol. Mass.:
370.707
SMILES:
OC(=O)[C@H]1[C@@H]2Oc3cc(Oc4ccc(cc4Cl)C(F)(F)F)ccc3[C@H]12 |r|
Structure:
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