Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM50256744
Substrate
n/a
Meas. Tech.
ChEMBL_519599 (CHEMBL943674)
EC50
10±n/a nM
Citation
 Bharate, SB; Rodge, A; Joshi, RK; Kaur, J; Srinivasan, S; Kumar, SS; Kulkarni-Almeida, A; Balachandran, S; Balakrishnan, A; Vishwakarma, RA Discovery of diacylphloroglucinols as a new class of GPR40 (FFAR1) agonists. Bioorg Med Chem Lett 18:6357-61 (2008) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM50256744
Synonyms:
3-(4-(5-(thiophen-2-yl)-2,3-dihydro-1H-inden-1-yloxy)phenyl)hex-4-ynoic acid | CHEMBL514337
Type:
Small organic molecule
Emp. Form.:
C25H22O3S
Mol. Mass.:
402.505
SMILES:
CC#CC(CC(O)=O)c1ccc(OC2CCc3cc(ccc23)-c2cccs2)cc1
Structure:
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