Reaction Details Report a problem with these data
Target
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Ligand
BDBM50240714
Substrate
n/a
Meas. Tech.
ChEMBL_560474 (CHEMBL1020494)
Ki
58000±n/a nM
Citation
 Kotthaus, J; Schade, D; Muschick, N; Beitz, E; Clement, B Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads. Bioorg Med Chem 16:10205-9 (2008) [PubMed]  Article 
Target
Name:
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Synonyms:
DDAH | DDAH1 | DDAH1_HUMAN | Dimethylarginine dimethylaminohydrolase (DDAH-1) | Dimethylarginine dimethylaminohydrolase 1 (DDAH) | Dimethylarginine dimethylaminohydrolase 1 (DDAH) E78A | Dimethylarginine dimethylaminohydrolase 1 (DDAH) L271G | Dimethylarginine dimethylaminohydrolase 1 (DDAH) L30A | Dimethylarginine dimethylaminohydrolase 1 (DDAH1) | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Type:
Protein
Mol. Mass.:
31116.90
Organism:
Homo sapiens (Human)
Description:
O94760
Residue:
285
Sequence:
MAGLGHPAAFGRATHAVVRALPESLGQHALRSAKGEEVDVARAERQHQLYVGVLGSKLGLQVVELPADESLPDCVFVEDVAVVCEETALITRPGAPSRRKEVDMMKEALEKLQLNIVEMKDENATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFKDYAVSTVPVADGLHLKSFCSMAGPNLIAIGSSESAQKALKIMQQMSDHRYDKLTVPDDIAANCIYLNIPNKGHVLLHRTPEEYPESAKVYEKLKDHMLIPVSMSELEKVDGLLTCCSVLINKKVDS
  
Inhibitor
Name:
BDBM50240714
Synonyms:
(2S)-5-{[(allylamino)(iminio)methyl]amino}-2-ammoniopentanoate | (S)-5-(N'-Allyl-guanidino)-2-amino-pentanoic acid | CHEMBL106425 | N-omega-allyl-L-arginine
Type:
Small organic molecule
Emp. Form.:
C9H18N4O2
Mol. Mass.:
214.2648
SMILES:
N[C@@H](CCCN=C(N)NCC=C)C(O)=O |r,w:5.4|
Structure:
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