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Target
B1 bradykinin receptor
Ligand
BDBM50254458
Substrate
n/a
Meas. Tech.
ChEMBL_560709 (CHEMBL1010844)
Ki
267±n/a nM
Citation
 Cole, AG; Metzger, A; Brescia, MR; Qin, LY; Appell, KC; Brain, CT; Hallett, A; Ganju, P; Denholm, AA; Wareing, JR; Ritchie, TJ; Drake, GM; Bevan, SJ; MacGloinn, A; McBryde, A; Patel, V; Oakley, PJ; Nunez, X; Gstach, H; Schneider, P; Baldwin, JJ; Dolle, RE; McDonald, E; Henderson, I Sulfonamido-aryl ethers as bradykinin B1 receptor antagonists. Bioorg Med Chem Lett 19:119-22 (2008) [PubMed]  Article 
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Homo sapiens (Human)
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
  
Inhibitor
Name:
BDBM50254458
Synonyms:
CHEMBL452238 | N-(2-chlorobenzyl)-2-(N-(4-isobutoxy-3-methoxybenzyl)-4-(piperidin-1-ylmethyl)phenylsulfonamido)acetamide
Type:
Small organic molecule
Emp. Form.:
C33H42ClN3O5S
Mol. Mass.:
628.222
SMILES:
COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCCCC3)cc2)ccc1OCC(C)C
Structure:
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