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Found 352 with Last Name = 'metzger' and Initial = 'a'
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16318(3-({5-cyano-6-[(2,2-dimethylpropyl)(methyl)amino]-...)
Affinity DataKi:  0.0470nM ΔG°:  -58.4kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16319(3-({2-amino-5-cyano-6-[(2,2-dimethylpropyl)(methyl...)
Affinity DataKi:  0.0500nM ΔG°:  -58.2kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16329(3-({2-amino-5-cyano-6-[(1-methylethyl)amino]pyrimi...)
Affinity DataKi:  0.0570nM ΔG°:  -57.9kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16317(3-({5-cyano-6-[(2,2-dimethylpropyl)(methyl)amino]-...)
Affinity DataKi:  0.0570nM ΔG°:  -57.9kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16320(3-({5-cyano-6-[(2,2-dimethylpropyl)(methyl)amino]p...)
Affinity DataKi:  0.150nM ΔG°:  -55.5kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16330(3-{[2-amino-5-cyano-6-(cyclopentylamino)pyrimidin-...)
Affinity DataKi:  0.160nM ΔG°:  -55.3kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16325(3-({5-cyano-6-[(1-methylethyl)amino]pyrimidin-4-yl...)
Affinity DataKi:  0.410nM ΔG°:  -53.0kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16324(3-{[5-cyano-6-(cyclopentylamino)pyrimidin-4-yl]ami...)
Affinity DataKi:  0.420nM ΔG°:  -53.0kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16323(3-({5-cyano-6-[(1-methylethyl)amino]pyrimidin-4-yl...)
Affinity DataKi:  0.610nM ΔG°:  -52.1kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16322(3-{[5-cyano-6-(propylamino)pyrimidin-4-yl]amino}-N...)
Affinity DataKi:  0.970nM ΔG°:  -50.9kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16331(3-({2-amino-5-cyano-6-[(1-methylethyl)amino]pyrimi...)
Affinity DataKi:  1.5nM ΔG°:  -49.9kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16326(3-{[5-cyano-6-(cyclopentylamino)pyrimidin-4-yl]ami...)
Affinity DataKi:  1.60nM ΔG°:  -49.7kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16332(3-{[2-amino-5-cyano-6-(cyclopentylamino)pyrimidin-...)
Affinity DataKi:  1.90nM ΔG°:  -49.3kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16316(3-({4-[(2,2-dimethylpropyl)(methyl)amino]-6-(4-met...)
Affinity DataKi:  3.70nM ΔG°:  -47.6kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50254456(CHEMBL447392 | N-(2-chlorobenzyl)-2-(N-(4-isobutox...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]desArg from human B1 in human WI 38 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50266051((4-(furan-2-yl)-2-(2-(thiophen-2-yl)ethylamino)thi...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]SCH-58261 from human recombinant adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16328(3-{[5-cyano-6-(cyclopentylamino)pyrimidin-4-yl]ami...)
Affinity DataKi:  14nM ΔG°:  -44.4kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16327(3-({5-cyano-6-[(1-methylethyl)amino]pyrimidin-4-yl...)
Affinity DataKi:  15nM ΔG°:  -44.2kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16321(3-{[5-cyano-6-(methylamino)pyrimidin-4-yl]amino}-N...)
Affinity DataKi:  16nM ΔG°:  -44.0kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50254457(CHEMBL443207 | N-(2-chlorobenzyl)-2-(N-(3-chloro-4...)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]desArg from human B1 in human WI 38 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50254458(CHEMBL452238 | N-(2-chlorobenzyl)-2-(N-(4-isobutox...)
Affinity DataKi:  34nMAssay Description:Displacement of [3H]desArg from human B1 in human WI 38 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50254456(CHEMBL447392 | N-(2-chlorobenzyl)-2-(N-(4-isobutox...)
Affinity DataKi:  37nMAssay Description:Antagonist activity at human cloned B1 receptor expressed in african green monkey COS7 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50266020((4-(furan-2-yl)-2-(furan-2-ylmethylamino)thiazol-5...)
Affinity DataKi:  43nMAssay Description:Displacement of [3H]SCH-58261 from human recombinant adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50266021((4-(furan-2-yl)-2-(thiophen-2-ylmethylamino)thiazo...)
Affinity DataKi:  54nMAssay Description:Displacement of [3H]SCH-58261 from human recombinant adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50266022((2-(2-(benzo[d][1,3]dioxol-5-yl)ethylamino)-4-(fur...)
Affinity DataKi:  61nMAssay Description:Displacement of [3H]SCH-58261 from human recombinant adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50266019((2-(3,4-difluorobenzylamino)-4-(furan-2-yl)thiazol...)
Affinity DataKi:  64nMAssay Description:Displacement of [3H]SCH-58261 from human recombinant adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50265981((4-(furan-2-yl)-2-(methylamino)thiazol-5-yl)(pheny...)
Affinity DataKi:  67nMAssay Description:Displacement of [3H]SCH-58261 from human recombinant adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50266084((2-(benzyl(furan-2-ylmethyl)amino)-4-(furan-2-yl)t...)
Affinity DataKi:  88nMAssay Description:Displacement of [3H]SCH-58261 from human recombinant adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50265982((4-(furan-2-yl)-2-(isobutylamino)thiazol-5-yl)(phe...)
Affinity DataKi:  89nMAssay Description:Displacement of [3H]SCH-58261 from human recombinant adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50254459(CHEMBL512111 | N-(2-chlorobenzyl)-2-(N-(4-isobutox...)
Affinity DataKi:  93nMAssay Description:Displacement of [3H]desArg from human B1 in human WI 38 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50266018((2-(1-(2-fluorobenzyl)piperidin-4-ylamino)-4-(fura...)
Affinity DataKi:  105nMAssay Description:Displacement of [3H]SCH-58261 from human recombinant adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50266052((4-(furan-2-yl)-2-(3-phenylpropylamino)thiazol-5-y...)
Affinity DataKi:  105nMAssay Description:Displacement of [3H]SCH-58261 from human recombinant adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50254460(CHEMBL499999 | N-(2-chlorobenzyl)-2-(N-(4-isobutox...)
Affinity DataKi:  113nMAssay Description:Displacement of [3H]desArg from human B1 in human WI 38 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50254461(CHEMBL507546 | N-(2-chlorobenzyl)-2-(N-(4-isobutox...)
Affinity DataKi:  149nMAssay Description:Displacement of [3H]desArg from human B1 in human WI 38 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50265984((4-(furan-2-yl)-2-(2-methoxypropylamino)thiazol-5-...)
Affinity DataKi:  154nMAssay Description:Displacement of [3H]SCH-58261 from human recombinant adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50266055((4-(furan-2-yl)-2-((furan-2-ylmethyl)(methyl)amino...)
Affinity DataKi:  160nMAssay Description:Displacement of [3H]SCH-58261 from human recombinant adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50254457(CHEMBL443207 | N-(2-chlorobenzyl)-2-(N-(3-chloro-4...)
Affinity DataKi:  188nMAssay Description:Antagonist activity at human cloned B1 receptor expressed in african green monkey COS7 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50265983((4-(furan-2-yl)-2-(2-methoxyethylamino)thiazol-5-y...)
Affinity DataKi:  195nMAssay Description:Displacement of [3H]SCH-58261 from human recombinant adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50254462(CHEMBL468492 | N-(2-methoxyphenethyl)-2-(N-(2-(ben...)
Affinity DataKi:  210nMAssay Description:Displacement of [3H]desArg from human B1 in human WI 38 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50254458(CHEMBL452238 | N-(2-chlorobenzyl)-2-(N-(4-isobutox...)
Affinity DataKi:  267nMAssay Description:Antagonist activity at human cloned B1 receptor expressed in african green monkey COS7 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50265985(CHEMBL460172 | N-(2-(5-benzoyl-4-(furan-2-yl)thiaz...)
Affinity DataKi:  281nMAssay Description:Displacement of [3H]SCH-58261 from human recombinant adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50254463(3-(2-(2,4-dichloro-N-(2-(2,3-dihydro-1H-inden-5-yl...)
Affinity DataKi:  410nMAssay Description:Displacement of [3H]desArg from human B1 in human WI 38 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50265986(1-(4-(5-benzoyl-4-(furan-2-yl)thiazol-2-ylamino)pi...)
Affinity DataKi:  455nMAssay Description:Displacement of [3H]SCH-58261 from human recombinant adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50254461(CHEMBL507546 | N-(2-chlorobenzyl)-2-(N-(4-isobutox...)
Affinity DataKi:  463nMAssay Description:Antagonist activity at human cloned B1 receptor expressed in african green monkey COS7 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50254459(CHEMBL512111 | N-(2-chlorobenzyl)-2-(N-(4-isobutox...)
Affinity DataKi:  497nMAssay Description:Antagonist activity at human cloned B1 receptor expressed in african green monkey COS7 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50254508(3-(2-(2,4-dichloro-N-(2-(3-chlorophenoxy)ethyl)phe...)
Affinity DataKi:  1.09E+3nMAssay Description:Displacement of [3H]desArg from human B1 in human WI 38 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50254632(2-(2,4-dichloro-N-(2-(2,3-dihydro-1H-inden-5-yloxy...)
Affinity DataKi:  1.21E+3nMAssay Description:Displacement of [3H]desArg from human B1 in human WI 38 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50265986(1-(4-(5-benzoyl-4-(furan-2-yl)thiazol-2-ylamino)pi...)
Affinity DataKi:  1.24E+3nMAssay Description:Displacement of [3H]DPCPX from human recombinant adenosine A1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50265982((4-(furan-2-yl)-2-(isobutylamino)thiazol-5-yl)(phe...)
Affinity DataKi:  1.28E+3nMAssay Description:Displacement of [3H]DPCPX from human recombinant adenosine A1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50266020((4-(furan-2-yl)-2-(furan-2-ylmethylamino)thiazol-5...)
Affinity DataKi:  1.46E+3nMAssay Description:Displacement of [3H]DPCPX from human recombinant adenosine A1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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