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Target
Baculoviral IAP repeat-containing protein 8
Ligand
BDBM50273699
Substrate
n/a
Meas. Tech.
ChEMBL_537310 (CHEMBL985406)
Ki
4.2±n/a nM
Citation
 Peng, Y; Sun, H; Nikolovska-Coleska, Z; Qiu, S; Yang, CY; Lu, J; Cai, Q; Yi, H; Kang, S; Yang, D; Wang, S Potent, orally bioavailable diazabicyclic small-molecule mimetics of second mitochondria-derived activator of caspases. J Med Chem 51:8158-62 (2008) [PubMed]  Article 
Target
Name:
Baculoviral IAP repeat-containing protein 8
Synonyms:
BIRC8 | BIRC8_HUMAN | ILP2
Type:
PROTEIN
Mol. Mass.:
27091.98
Organism:
Homo sapiens (Human)
Description:
ChEMBL_537310
Residue:
236
Sequence:
MTGYEARLITFGTWMYSVNKEQLARAGFYAIGQEDKVQCFHCGGGLANWKPKEDPWEQHAKWYPGCKYLLEEKGHEYINNIHLTRSLEGALVQTTKKTPSLTKRISDTIFPNPMLQEAIRMGFDFKDVKKIMEERIQTSGSNYKTLEVLVADLVSAQKDTTENELNQTSLQREISPEEPLRRLQEEKLCKICMDRHIAVVFIPCGHLVTCKQCAEAVDRCPMCSAVIDFKQRVFMS
  
Inhibitor
Name:
BDBM50273699
Synonyms:
(5S,8S,10aR)-N-Benzhydryl-5-((S)-2-(methyl-amino)propanamido)-6-oxo-3-(2-phenyl-acetyl)decahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide | CHEMBL504559 | SM-337
Type:
Small organic molecule
Emp. Form.:
C35H41N5O4
Mol. Mass.:
595.7311
SMILES:
CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(c1ccccc1)c1ccccc1)C(=O)Cc1ccccc1 |r|
Structure:
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