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Target
Type-1 angiotensin II receptor B
Ligand
BDBM50048078
Substrate
n/a
Meas. Tech.
ChEMBL_34831 (CHEMBL648765)
IC50
1±n/a nM
Citation
 Weinstock, J; Hill, DT; Keenan, RM; Franz, RG; Gaitanopoulos, DE; Girard, GR; Eggleston, DS; Aiyar, N; Griffin, E; Ohlstein, E; Brooks, DP; Gellai, M; Frederickson, TA; Weidley, EF; Edwards, RM A potent long-acting imidazole-5-acrylic acid angiotensin II AT-1 receptor antagonist Bioorg Med Chem Lett 4:23-28 (1994)    Article 
Target
Name:
Type-1 angiotensin II receptor B
Synonyms:
AGTRB_RAT | AT3 | Agtr1 | Agtr1b | Angiotensin II AT1B | Angiotensin II receptor (AT-1) type-1 | Angiotensin II type 1b (AT-1b) receptor | At1b | Type-1B angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40929.44
Organism:
RAT
Description:
Angiotensin II AT1B 0 RAT::P29089
Residue:
359
Sequence:
MTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKAYKIQKNTPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKMSTLSYRPSDNMSSSAKKSASFFEVE
  
Inhibitor
Name:
BDBM50048078
Synonyms:
4-[2-Butyl-5-((E)-2-carboxy-3-thiophen-2-yl-propenyl)-imidazol-1-ylmethyl]-2-chloro-benzoic acid | 4-[2-Butyl-5-(2-carboxy-3-thiophen-2-yl-propenyl)-imidazol-1-ylmethyl]-2-chloro-benzoic acid | CHEMBL57309
Type:
Small organic molecule
Emp. Form.:
C23H23ClN2O4S
Mol. Mass.:
458.958
SMILES:
CCCCc1ncc(\C=C(/Cc2cccs2)C(O)=O)n1Cc1ccc(C(O)=O)c(Cl)c1
Structure:
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