Reaction Details Report a problem with these data
Target
Gag-Pol polyprotein [489-587]
Ligand
BDBM50403366
Substrate
n/a
Meas. Tech.
ChEMBL_79807 (CHEMBL696067)
IC50
37±n/a nM
Citation
 Vacca, JP; Fitzgerald, PM; Holloway, MK; Hungate, RW; Starbuck, KE; Chen, LJ; Darke, PL; Anderson, PS; Huff, JR Conformationally constrained HIV-1 protease inhibitors Bioorg Med Chem Lett 4:499-504 (1994)    Article 
Target
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10781.16
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
  
Inhibitor
Name:
BDBM50403366
Synonyms:
CHEMBL2062145 | L-687630
Type:
Small organic molecule
Emp. Form.:
C35H42N2O5
Mol. Mass.:
570.7184
SMILES:
CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C[C@@]1(Cc2ccccc2)CCN([C@@H]2[C@H](O)Cc3ccccc23)C1=O |r|
Structure:
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