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Target
Gag-Pol polyprotein [489-587]
Ligand
BDBM50283954
Substrate
n/a
Meas. Tech.
ChEMBL_79807 (CHEMBL696067)
IC50
14±n/a nM
Citation
 Vacca, JP; Fitzgerald, PM; Holloway, MK; Hungate, RW; Starbuck, KE; Chen, LJ; Darke, PL; Anderson, PS; Huff, JR Conformationally constrained HIV-1 protease inhibitors Bioorg Med Chem Lett 4:499-504 (1994)    Article 
Target
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10781.16
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
  
Inhibitor
Name:
BDBM50283954
Synonyms:
CHEMBL146361 | {(1S,2S)-1-Benzyl-3-[(S)-3-benzyl-1-((1S,2R,5R)-2-hydroxy-5-methyl-cyclopentyl)-2-oxo-pyrrolidin-3-yl]-2-hydroxy-propyl}-carbamic acid tert-butyl ester
Type:
Small organic molecule
Emp. Form.:
C32H44N2O5
Mol. Mass.:
536.7022
SMILES:
C[C@@H]1CC[C@@H](O)[C@H]1N1CC[C@](C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)(Cc2ccccc2)C1=O
Structure:
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