Reaction Details Report a problem with these data
Target
Sodium- and chloride-dependent GABA transporter 2
Ligand
BDBM50403565
Substrate
n/a
Meas. Tech.
ChEBML_70051
IC50
447000±n/a nM
Citation
 Dhar, TG; Nakanishi, H; Borden, LA; Gluchowski, C On the bioactive conformation of the gaba uptake inhibitor SK&F 89976-A Bioorg Med Chem Lett 6:1535-1540 (1996)    Article 
Target
Name:
Sodium- and chloride-dependent GABA transporter 2
Synonyms:
GABA transporter | GABA transporter 2 | Gabt2 | Gat-2 | S6A13_RAT | Slc6a13
Type:
PROTEIN
Mol. Mass.:
68261.89
Organism:
Rattus norvegicus
Description:
ChEMBL_70051
Residue:
602
Sequence:
MDNRVSGTTSNGETKPVCPVMEKVEEDGTLEREQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLIFLFTCGIPVFFLETALGQYTNQGGITAWRKICPIFEGIGYASQMIVSLLNVYYIVVLAWALFYLFSSFTTDLPWGSCSHEWNTENCVEFQKTNNSLNVTSENATSPVIEFWERRVLKISDGIQHLGSLRWELVLCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNITRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCVALCILNSSTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPRVFRKKNRREILILIVSVVSFFIGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGASRFYDNIEDMIGYKPWPLIKYCWLFFTPAVCLATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSIYKLRTLKGPLRERLRQLVCPAEDLPQKSQPELTSPATPMTSLLRLTELESNC
  
Inhibitor
Name:
BDBM50403565
Synonyms:
CHEMBL2093978
Type:
Small organic molecule
Emp. Form.:
C23H27NO2
Mol. Mass.:
349.466
SMILES:
OC(=O)[C@@H]1CCC2C[C@@H](CCN2C1)C(c1ccccc1)c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: