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Target
Endothelin-1 receptor
Ligand
BDBM50289648
Substrate
n/a
Meas. Tech.
ChEBML_65329
IC50
>100±n/a nM
Citation
 Suzawa, T; Shibata, K; Tanaka, T; Matsuda, Y; Yamasaki, M RES-701-1/endothelin-1 hybrid peptide having a potent binding activity for type B receptor Bioorg Med Chem Lett 7:1715-1720 (1997)    Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA | EDNRA_BOVIN | ET-A | Endothelin A receptor | Endothelin receptor ET-A | Endothelin-1 receptor
Type:
PROTEIN
Mol. Mass.:
48527.56
Organism:
Bos taurus
Description:
ChEMBL_65329
Residue:
427
Sequence:
METFWLRLSFWVALVGGVISDNPESYSTNLSIHVDSVATFHGTELSFVVTTHQPTNLALPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFEQNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYKGAQHRTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDTNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHEQNNHNTERSSHKDSIN
  
Inhibitor
Name:
BDBM50289648
Synonyms:
CHEMBL408437 | Compound RES-701-1(1-10)/[A15]SRTX6b
Type:
Small organic molecule
Emp. Form.:
C116H147N29O28
Mol. Mass.:
2395.5859
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CC(=O)NCC(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2cnc[nH]2)C(=O)NCC(=O)N[C@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N2CCC[C@@H]2C(=O)N1)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O
Structure:
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