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Target
Neuromedin-K receptor
Ligand
BDBM50290461
Substrate
n/a
Meas. Tech.
ChEMBL_142725 (CHEMBL745029)
Ki
5.5±n/a nM
Citation
 Fauchère, JL; Kucharczyk, N; Jacoby, E; Lonchampt, M; Robineau, P; Dacquet, C; Regoli, D; Canet, E The dipeptide neurokinin-1 receptor antagonist S19752 is a potent and long-acting inhibitor of bronchoconstriction when administered by aerosol to the guinea pig in vivo Bioorg Med Chem Lett 7:203-208 (1997)    Article 
Target
Name:
Neuromedin-K receptor
Synonyms:
NK3R_RAT | Neurokinin 3 receptor | Tac3r | Tacr3
Type:
n/a
Mol. Mass.:
51128.60
Organism:
Rattus norvegicus
Description:
ChEMBL_10983
Residue:
452
Sequence:
MASVPRGENWTDGTVEVGTHTGNLSSALGVTEWLALQAGNFSSALGLPATTQAPSQVRANLTNQFVQPSWRIALWSLAYGLVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASVAAFNTLINFIYGLHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKIKVMPGRTLCYVQWPEGPKQHFTYHIIVIILVYCFPLLIMGVTYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKMMIIVVVTFAICWLPYHVYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIQVSSYDELELKTTRFHPTRQSSLYTVSRMESVTVLFDPNDGDPTKSSRKKRAVPRDPSANGCSHRGSKSASTTSSFISSPYTSVDEYS
  
Inhibitor
Name:
BDBM50290461
Synonyms:
CHEMBL65468 | potassium 3,5-di(trifluoromethyl)benzyl 2-[4-hydroxy-1-{1-[4-(1H-1,2,3,4-tetraazol-5-yl)butyl]-1H-3-indolylcarbonyl}-(2R,4S)-tetrahydro-1H-2-pyrrolylcarboxamido]-3-(1H-3-indolyl)-(2S)-propanoate
Type:
Small organic molecule
Emp. Form.:
C39H35F6N8O5
Mol. Mass.:
809.7368
SMILES:
OC1CC(N(C1)C(=O)c1cn(CCCCc2nn[n-]n2)c2ccccc12)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Structure:
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