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Target
G-protein coupled receptor homolog US28
Ligand
BDBM50027202
Substrate
n/a
Meas. Tech.
ChEMBL_321572 (CHEMBL881787)
IC50
15800±n/a nM
Citation
 Hulshof, JW; Casarosa, P; Menge, WM; Kuusisto, LM; van der Goot, H; Smit, MJ; de Esch, IJ; Leurs, R Synthesis and structure-activity relationship of the first nonpeptidergic inverse agonists for the human cytomegalovirus encoded chemokine receptor US28. J Med Chem 48:6461-71 (2005) [PubMed]  Article 
Target
Name:
G-protein coupled receptor homolog US28
Synonyms:
Human herpesvirus 5 chemokine receptor | US28 | US28_HCMVA
Type:
PROTEIN
Mol. Mass.:
41070.46
Organism:
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Description:
ChEMBL_322135
Residue:
354
Sequence:
MTPTTTTAELTTEFDYDEDATPCVFTDVLNQSKPVTLFLYGVVFLFGSIGNFLVIFTITWRRRIQCSGDVYFINLAAADLLFVCTLPLWMQYLLDHNSLASVPCTLLTACFYVAMFASLCFITEIALDRYYAIVYMRYRPVKQACLFSIFWWIFAVIIAIPHFMVVTKKDNQCMTDYDYLEVSYPIILNVELMLGAFVIPLSVISYCYYRISRIVAVSQSRHKGRIVRVLIAVVLVFIIFWLPYHLTLFVDTLKLLKWISSSCEFERSLKRALILTESLAFCHCCLNPLLYVFVGTKFRQELHCLLAEFRQRLFSRDVSWYHSMSFSRRSSPSRRETSSDTLSDEVCRVSQIIP
  
Inhibitor
Name:
BDBM50027202
Synonyms:
4-(4-Chloro-phenyl)-1-[4-(3,4-dichloro-phenyl)-4-phenyl-butyl]-piperidin-4-ol | CHEMBL198332
Type:
Small organic molecule
Emp. Form.:
C27H28Cl3NO
Mol. Mass.:
488.876
SMILES:
OC1(CCN(CCCC(c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1)c1ccc(Cl)cc1
Structure:
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