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Found 672 with Last Name = 'smit' and Initial = 'mj'
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118719(7-Amino-3-{[1-(2-amino-3-cyclohexyl-propionyl)-pyr...)
Affinity DataKi:  0.140nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118730(7-Amino-3-(2-{[2-(carboxymethyl-amino)-3-cyclohexy...)
Affinity DataKi:  0.210nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118739(7-Amino-3-({1-[2-(carboxymethyl-amino)-3-cyclohexy...)
Affinity DataKi:  0.290nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118728(7-Amino-3-({1-[2-(carboxymethyl-amino)-3-cyclohexy...)
Affinity DataKi:  0.290nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118732(1-(2-Amino-3-phenyl-propionyl)-pyrrolidine-2-carbo...)
Affinity DataKi:  0.300nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118729(7-Amino-3-({1-[2-(carboxymethyl-amino)-3-cyclohexy...)
Affinity DataKi:  0.330nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118731((2-{2-[5-Amino-1-(oxazole-2-carbonyl)-pentylcarbam...)
Affinity DataKi:  0.420nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118735(7-Amino-3-({1-[2-(carboxymethyl-amino)-3-cyclohexy...)
Affinity DataKi:  0.5nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118738(7-Amino-3-({1-[2-(carboxymethyl-amino)-3-cyclohexy...)
Affinity DataKi:  0.820nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118718(CHEMBL343804 | {2-[2-(5-Amino-1-phenethylaminooxal...)
Affinity DataKi:  0.840nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118723(CHEMBL342672 | CYCLOTHEONAMIDE A | N-[14-Benzyl-18...)
Affinity DataKi:  1nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118727(2-((R)-1-((S)-2-(((S)-7-amino-1-isopropoxy-1,2-dio...)
Affinity DataKi:  1.10nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118720(7-Amino-3-{[1-(2-amino-3-phenyl-propionyl)-pyrroli...)
Affinity DataKi:  1.40nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM29388(Exanta | Melagatran | US11584714, Compound 999)
Affinity DataKi:  2nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118717((S)-N-((S)-6-amino-1-oxo-1-(thiazol-2-yl)hexan-2-y...)
Affinity DataKi:  2nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118737((2-{2-[5-Amino-1-(thiazole-2-carbonyl)-pentylcarba...)
Affinity DataKi:  2.60nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50337250((S)-5-chloro-6-(4-(1-(4-chlorobenzyl)piperidin-4-y...)
Affinity DataKi:  3.16nMAssay Description:Displacement of [125I]CXCL10 from human CXCR3 expressed in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118721((S)-N-((S)-6-amino-1-oxo-1-(thiazol-2-yl)hexan-2-y...)
Affinity DataKi:  3.5nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50008294(2-(4-(((2-amino-4-oxo-1,4-dihydroquinazolin-6-yl)m...)
Affinity DataKi:  4.5nMAssay Description:Binding affinity was evaluated against thymidylate synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50037996(1-[N-(naphthalen-2-ylsulfonyl)glycyl-4-carbamimido...)
Affinity DataKi:  6nMAssay Description:The compound was evaluated in vitro for the thrombin inhibition.More data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50060033(3-[3-(4-Methyl-piperidin-1-yl)-2-(naphthalene-2-su...)
Affinity DataKi:  6.20nMAssay Description:The compound was evaluated in vitro for the thrombin inhibition.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtypical chemokine receptor 3(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50380130(CHEMBL2013230)
Affinity DataKi:  7.94nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR7 expressed in HEK293 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50310502((R)-N-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydropyri...)
Affinity DataKi:  10nMAssay Description:Displacement of [125I]CXCL10 from CXCR3 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtypical chemokine receptor 3(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50380114(CHEMBL2013216)
Affinity DataKi:  12.6nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR7 expressed in HEK293 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118722(2-Amino-N-{[5-amino-1-(thiazole-2-carbonyl)-pentyl...)
Affinity DataKi:  13nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50184539((2S)-2-(6-butyl-2-(4-(4-(trifluoromethyl)phenyl)-1...)
Affinity DataKi:  14nMAssay Description:Binding affinity to human CXCR2 receptor transfected in CHO cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50008294(2-(4-(((2-amino-4-oxo-1,4-dihydroquinazolin-6-yl)m...)
Affinity DataKi:  14nMAssay Description:Binding affinity was evaluated against dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118725(7-Amino-3-{[1-(3-carboxy-2-phenylmethanesulfonylam...)
Affinity DataKi:  15nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtypical chemokine receptor 3(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50380134(CHEMBL2013215)
Affinity DataKi:  15.8nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR7 expressed in HEK293 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50184530((2S)-2-(6-butyl-2-(4-(4-(trifluoromethoxy)phenyl)-...)
Affinity DataKi:  17nMAssay Description:Binding affinity to human CXCR2 receptor transfected in CHO cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50038001((2R,4R)-1-((S)-5-(diaminomethyleneamino)-2-(3-meth...)
Affinity DataKi:  19nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtypical chemokine receptor 3(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50380131(CHEMBL2013231)
Affinity DataKi:  19.9nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR7 expressed in HEK293 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50184531((2S)-N-(3-ethoxypropyl)-4-methyl-2-(6-propyl-2-(4-...)
Affinity DataKi:  25nMAssay Description:Binding affinity to human CXCR2 receptor transfected in CHO cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtypical chemokine receptor 3(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50380121(CHEMBL2013219)
Affinity DataKi:  25.1nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR7 expressed in HEK293 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50184518((2S)-2-(6-butyl-2-(4-(4-chlorophenyl)-1H-imidazol-...)
Affinity DataKi:  27nMAssay Description:Binding affinity to human CXCR2 receptor transfected in CHO cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118734(6-Amino-2-[2-(5-{[1-(2-amino-3-phenyl-propionyl)-p...)
Affinity DataKi:  28nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtypical chemokine receptor 3(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50380123(CHEMBL2013222)
Affinity DataKi:  31.6nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR7 expressed in HEK293 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50184527((2S)-2-(6-butyl-2-(4-(4-hydroxyphenyl)-1H-imidazol...)
Affinity DataKi:  32nMAssay Description:Binding affinity to human CXCR2 receptor transfected in CHO cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Osaka University

Curated by ChEMBL
LigandPNGBDBM50121205(CHEBI:18295 | Histamine)
Affinity DataKi:  34nMAssay Description:Histamine H3 receptor competition binding using [3H]Na-methylhistamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50184540((2S)-N-(3-ethoxypropyl)-4-methyl-2-(6-propyl-2-(4-...)
Affinity DataKi:  35nMAssay Description:Binding affinity to human CXCR2 receptor transfected in CHO cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50184536((2S)-2-(6-butyl-2-(4-(4-fluorophenyl)-1H-imidazol-...)
Affinity DataKi:  37nMAssay Description:Binding affinity to human CXCR2 receptor transfected in CHO cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50211114((-)-(R)-N-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydro...)
Affinity DataKi:  39.8nMAssay Description:Displacement of [125I]-CXCL10 from human CXCR3 expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50399980(CHEMBL2181467)
Affinity DataKi:  39.8nMAssay Description:Displacement of [125I]CXCL10 from CXCR3 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50184535((2S)-2-(6-butyl-2-(4-p-tolyl-1H-imidazol-1-yl)pyri...)
Affinity DataKi:  40nMAssay Description:Binding affinity to human CXCR2 receptor transfected in CHO cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50184521((2S)-2-(6-butyl-2-(4-(4-methoxyphenyl)-1H-imidazol...)
Affinity DataKi:  42nMAssay Description:Binding affinity to human CXCR2 receptor transfected in CHO cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50184523((2S)-2-(6-butyl-2-(4-(4-cyanophenyl)-1H-imidazol-1...)
Affinity DataKi:  43nMAssay Description:Binding affinity to human CXCR2 receptor transfected in CHO cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50184517((2S)-N-(3-ethoxypropyl)-4-methyl-2-(6-methyl-2-(4-...)
Affinity DataKi:  44nMAssay Description:Binding affinity to human CXCR2 receptor transfected in CHO cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50184537((2S)-N-(3-ethoxypropyl)-4-methyl-2-(6-propyl-2-(4-...)
Affinity DataKi:  50nMAssay Description:Binding affinity to human CXCR2 receptor transfected in CHO cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtypical chemokine receptor 3(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50380125(CHEMBL2013224)
Affinity DataKi:  50.1nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR7 expressed in HEK293 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50399981(CHEMBL2181450)
Affinity DataKi:  50.1nMAssay Description:Displacement of [125I]CXCL10 from CXCR3 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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