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Target
G-protein coupled receptor homolog US28
Ligand
BDBM50027197
Substrate
n/a
Meas. Tech.
ChEMBL_322135 (CHEMBL885194)
EC50
>100000±n/a nM
Citation
 Hulshof, JW; Casarosa, P; Menge, WM; Kuusisto, LM; van der Goot, H; Smit, MJ; de Esch, IJ; Leurs, R Synthesis and structure-activity relationship of the first nonpeptidergic inverse agonists for the human cytomegalovirus encoded chemokine receptor US28. J Med Chem 48:6461-71 (2005) [PubMed]  Article 
Target
Name:
G-protein coupled receptor homolog US28
Synonyms:
Human herpesvirus 5 chemokine receptor | US28 | US28_HCMVA
Type:
PROTEIN
Mol. Mass.:
41070.46
Organism:
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Description:
ChEMBL_322135
Residue:
354
Sequence:
MTPTTTTAELTTEFDYDEDATPCVFTDVLNQSKPVTLFLYGVVFLFGSIGNFLVIFTITWRRRIQCSGDVYFINLAAADLLFVCTLPLWMQYLLDHNSLASVPCTLLTACFYVAMFASLCFITEIALDRYYAIVYMRYRPVKQACLFSIFWWIFAVIIAIPHFMVVTKKDNQCMTDYDYLEVSYPIILNVELMLGAFVIPLSVISYCYYRISRIVAVSQSRHKGRIVRVLIAVVLVFIIFWLPYHLTLFVDTLKLLKWISSSCEFERSLKRALILTESLAFCHCCLNPLLYVFVGTKFRQELHCLLAEFRQRLFSRDVSWYHSMSFSRRSSPSRRETSSDTLSDEVCRVSQIIP
  
Inhibitor
Name:
BDBM50027197
Synonyms:
4-(4-Chloro-phenyl)-1-(4-cyano-4,4-diphenyl-butyl)-4-hydroxy-1-methyl-piperidinium | CHEMBL199252
Type:
Small organic molecule
Emp. Form.:
C29H32ClN2O
Mol. Mass.:
460.03
SMILES:
C[N+]1(CCCC(C#N)(c2ccccc2)c2ccccc2)CCC(O)(CC1)c1ccc(Cl)cc1 |(1.44,1.79,;2.22,.44,;.68,.53,;-.16,-.75,;-1.69,-.68,;-2.53,-1.97,;-3.32,-.63,;-4.09,.71,;-1.84,-3.33,;-2.68,-4.61,;-2,-5.99,;-.46,-6.07,;.38,-4.78,;-.32,-3.41,;-4.07,-1.87,;-4.91,-3.15,;-6.43,-3.08,;-7.15,-1.71,;-6.29,-.4,;-4.77,-.5,;3.05,1.74,;4.59,1.65,;5.29,.28,;6.04,1.62,;4.44,-1,;2.9,-.92,;6.83,.2,;7.65,1.48,;9.19,1.4,;9.89,.02,;11.43,-.05,;9.05,-1.27,;7.51,-1.17,)|
Structure:
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