Reaction Details Report a problem with these data
Target
Retinoic acid receptor RXR-alpha
Ligand
BDBM50293410
Substrate
n/a
Meas. Tech.
ChEMBL_572202 (CHEMBL1029373)
EC50
576±n/a nM
Citation
 Pérez-Rodríguez, S; Ortiz, MA; Pereira, R; Rodríguez-Barrios, F; de Lera, AR; Piedrafita, FJ Highly twisted adamantyl arotinoids: synthesis, antiproliferative effects and RXR transactivation profiles. Eur J Med Chem 44:2434-46 (2009) [PubMed]  Article 
Target
Name:
Retinoic acid receptor RXR-alpha
Synonyms:
Nr2b1 | RXRA_MOUSE | Retinoid X receptor alpha | Rxra
Type:
PROTEIN
Mol. Mass.:
51225.80
Organism:
Mus musculus
Description:
ChEMBL_196493
Residue:
467
Sequence:
MDTKHFLPLDFSTQVNSSSLNSPTGRGSMAVPSLHPSLGPGIGSPLGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFGTGSPQLNSPMNPVSSTEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVEKILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQAT
  
Inhibitor
Name:
BDBM50293410
Synonyms:
(E)-3-[5'-(Adamant-1-yl)-2-chloro-4'-hydroxy-2'-methylbiphenyl-4-yl]acrylic acid | CHEMBL554740
Type:
Small organic molecule
Emp. Form.:
C26H27ClO3
Mol. Mass.:
422.944
SMILES:
Cc1cc(O)c(cc1-c1ccc(\C=C\C(O)=O)cc1Cl)C12CC3CC(CC(C3)C1)C2 |TLB:29:20:27:23.24.25,THB:29:24:27:21.20.28,28:20:23:27.25.26,28:26:23:21.20.29,5:20:27:23.24.25|
Structure:
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