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Target
B2 bradykinin receptor
Ligand
BDBM50293890
Substrate
n/a
Meas. Tech.
ChEMBL_572639 (CHEMBL1026063)
IC50
2.3±n/a nM
Citation
 Gibson, C; Schnatbaum, K; Pfeifer, JR; Locardi, E; Paschke, M; Reimer, U; Richter, U; Scharn, D; Faussner, A; Tradler, T Novel small molecule bradykinin B2 receptor antagonists. J Med Chem 52:4370-9 (2009) [PubMed]  Article 
Target
Name:
B2 bradykinin receptor
Synonyms:
B2 BRADYKININ | B2 bradykinin receptor | B2R | BDKRB2 | BK-2 receptor | BKR2 | BKRB2_HUMAN | Bradykinin B2 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44467.17
Organism:
Homo sapiens (Human)
Description:
B2 BRADYKININ BDKRB2 HUMAN::P30411
Residue:
391
Sequence:
MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQPPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNNFDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVITFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGILSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEPIQMENSMGTLRTSISVERQIHKLQDWAGSRQ
  
Inhibitor
Name:
BDBM50293890
Synonyms:
CHEMBL550827 | N-{5-chloro-4-[2-methyl-4-(2-methyl-2H-pyrazol-3-yl)-quinolin-8-yloxymethyl]-pyridin-3-ylmethyl}-isobutyramide
Type:
Small organic molecule
Emp. Form.:
C25H26ClN5O2
Mol. Mass.:
463.959
SMILES:
CC(C)C(=O)NCc1cncc(Cl)c1COc1cccc2c(cc(C)nc12)-c1ccnn1C
Structure:
Search PDB for entries with ligand similarity: