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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50296639
Substrate
n/a
Meas. Tech.
ChEMBL_582351 (CHEMBL1053415)
IC50
>1000±n/a nM
Citation
 Wurz, RP; Pettus, LH; Xu, S; Henkle, B; Sherman, L; Plant, M; Miner, K; McBride, H; Wong, LM; Saris, CJ; Lee, MR; Chmait, S; Mohr, C; Hsieh, F; Tasker, AS Part 1: Structure-Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase. Bioorg Med Chem Lett 19:4724-8 (2009) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50296639
Synonyms:
1-(2,6-difluorophenyl)-4-(4-fluorophenylamino)-7-methyl-1H-pyrazolo[3,4-b]pyridin-6(7H)-one | CHEMBL550596
Type:
Small organic molecule
Emp. Form.:
C19H13F3N4O
Mol. Mass.:
370.3279
SMILES:
Cn1c2n(ncc2c(Nc2ccc(F)cc2)cc1=O)-c1c(F)cccc1F |(11.11,-4.42,;11.11,-2.88,;9.78,-2.12,;8.3,-2.59,;7.39,-1.34,;8.3,-.09,;9.78,-.57,;11.11,.2,;11.11,1.74,;12.45,2.51,;13.77,1.73,;15.11,2.5,;15.11,4.04,;16.45,4.81,;13.77,4.81,;12.44,4.04,;12.44,-.58,;12.44,-2.12,;13.77,-2.89,;7.83,-4.06,;6.32,-4.37,;5.3,-3.22,;5.85,-5.83,;6.88,-6.98,;8.39,-6.65,;8.86,-5.19,;10.37,-4.86,)|
Structure:
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