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Found 1307 with Last Name = 'sherman' and Initial = 'l'
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Charles River

Curated by ChEMBL
LigandPNGBDBM50571467(CHEMBL4850755)
Affinity DataKi:  0.100nMAssay Description:Inhibition of full length recombinant FLAG-tagged human ATM assessed as decrease in p53 S15 phosphorylation using full length myc-tagged p53 as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50253105(6-Chloro-N-cyclopropyl-7-(1-((S)-3-methylmorpholin...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Charles River

Curated by ChEMBL
LigandPNGBDBM50571471(CHEMBL4858310 | US11685734, Example 213)
Affinity DataKi:  0.200nMAssay Description:Inhibition of full length recombinant FLAG-tagged human ATM assessed as decrease in p53 S15 phosphorylation using full length myc-tagged p53 as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50253148(CHEMBL522689 | N-(S)-sec-Butyl-6-(6-methyl-3-(meth...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50253150(CHEMBL493496 | N,6-Dimethyl-7-(1-((R)-3-methylmorp...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50253102(6-Methyl-7-(1-((S)-3-methylmorpholino)phthalazin-6...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Charles River

Curated by ChEMBL
LigandPNGBDBM50571463(CHEMBL4862803)
Affinity DataKi:  0.300nMAssay Description:Inhibition of full length recombinant FLAG-tagged human ATM assessed as decrease in p53 S15 phosphorylation using full length myc-tagged p53 as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50252776(CHEMBL495493 | N-Ethyl-6-methyl-7-(1-((S)-3-methyl...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50253103(7-(1-Isopropoxyphthalazin-6-yl)-N,6-dimethylbenzo[...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50252735(CHEMBL495084 | N-Cyclopropyl-6-methyl-7-(1-o-tolyl...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Charles River

Curated by ChEMBL
LigandPNGBDBM50571476(CHEMBL4852400 | US11685734, Example 215)
Affinity DataKi:  0.400nMAssay Description:Inhibition of full length recombinant FLAG-tagged human ATM assessed as decrease in p53 S15 phosphorylation using full length myc-tagged p53 as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50253149(6-Chloro-N-isopropyl-7-(1-((S)-3-methylmorpholino)...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50252777(CHEMBL523374 | N,6-Dimethyl-7-(1-((S)-3-methylmorp...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50252775(6-(3-(cyclopropylamino)-6-methylbenzo[d]isoxazol-7...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50253147(CHEMBL494305 | N-Isopropyl-6-(6-methyl-3-(methylam...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Charles River

Curated by ChEMBL
LigandPNGBDBM50550657(CHEMBL4792737)
Affinity DataKi:  0.5nMAssay Description:Inhibition of full length recombinant FLAG-tagged human ATM assessed as decrease in p53 S15 phosphorylation using full length myc-tagged p53 as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50253104(CHEMBL521860 | N-(6-Methyl-7-(1-((S)-3-methylmorph...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Charles River

Curated by ChEMBL
LigandPNGBDBM50571474(CHEMBL4857803 | US11685734, Example 211)
Affinity DataKi:  0.600nMAssay Description:Inhibition of full length recombinant FLAG-tagged human ATM assessed as decrease in p53 S15 phosphorylation using full length myc-tagged p53 as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314782(CHEMBL1089866 | N-Cyclopropyl-3-(1-(2,4-difluoroph...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50252736(CHEMBL522877 | N-Cyclopropyl-6-methyl-7-(1-((S)-3-...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314785(CHEMBL1091929 | N-Cyclopropyl-3-(1-(2,6-difluoroph...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50252774(1-((S)-4-(6-(3-(Cyclopropylamino)-6-methylbenzo[d]...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314778(3-(1-(2-Chlorophenyl)-7-methyl-6-oxo-6,7-dihydro-1...)
Affinity DataKi:  0.900nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Charles River

Curated by ChEMBL
LigandPNGBDBM50571475(CHEMBL4853948 | US11685734, Example 292)
Affinity DataKi:  0.900nMAssay Description:Inhibition of full length recombinant FLAG-tagged human ATM assessed as decrease in p53 S15 phosphorylation using full length myc-tagged p53 as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Charles River

Curated by ChEMBL
LigandPNGBDBM50571459(CHEMBL4872830)
Affinity DataKi:  1nMAssay Description:Inhibition of full length recombinant FLAG-tagged human ATM assessed as decrease in p53 S15 phosphorylation using full length myc-tagged p53 as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Charles River

Curated by ChEMBL
LigandPNGBDBM50571469(CHEMBL4852763 | US11685734, Example 270)
Affinity DataKi:  1nMAssay Description:Inhibition of full length recombinant FLAG-tagged human ATM assessed as decrease in p53 S15 phosphorylation using full length myc-tagged p53 as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Charles River

Curated by ChEMBL
LigandPNGBDBM50571468(CHEMBL4845919)
Affinity DataKi:  1nMAssay Description:Inhibition of full length recombinant FLAG-tagged human ATM assessed as decrease in p53 S15 phosphorylation using full length myc-tagged p53 as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Charles River

Curated by ChEMBL
LigandPNGBDBM50571466(CHEMBL4878312)
Affinity DataKi:  1nMAssay Description:Inhibition of full length recombinant FLAG-tagged human ATM assessed as decrease in p53 S15 phosphorylation using full length myc-tagged p53 as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314788(3-(1-(2,6-Difluorophenyl)-7-methyl-6-oxo-6,7-dihyd...)
Affinity DataKi:  1nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50253101(7-(1-Isopropylphthalazin-6-yl)-N,6-dimethylbenzo[d...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314784(4-Chloro-N-cyclopropyl-3-(1-(2,6-difluorophenyl)-7...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314776(CHEMBL1089865 | N-Cyclopropyl-3-(1-(2,6-difluoroph...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314786(3-(1-(2,6-Difluorophenyl)-7-methyl-6-oxo-6,7-dihyd...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314787(3-(1-(2,6-Difluorophenyl)-7-methyl-6-oxo-6,7-dihyd...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50252777(CHEMBL523374 | N,6-Dimethyl-7-(1-((S)-3-methylmorp...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of human recombinant GST-tagged p38beta-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314777(CHEMBL1089122 | N-Cyclopropyl-4-methyl-3-(7-methyl...)
Affinity DataKi:  1.90nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314781(CHEMBL1089534 | N-Cyclopropyl-3-(1-(2,5-difluoroph...)
Affinity DataKi:  1.90nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50252738(6-Methyl-7-(1-((S)-3-methylmorpholino)phthalazin-6...)
Affinity DataKi:  2nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314792(1-(2,6-Difluorophenyl)-7-methyl-5-(6-methyl-3-(met...)
Affinity DataKi:  2nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Charles River

Curated by ChEMBL
LigandPNGBDBM50571464(CHEMBL4874640 | US11685734, Example 43)
Affinity DataKi:  2nMAssay Description:Inhibition of full length recombinant FLAG-tagged human ATM assessed as decrease in p53 S15 phosphorylation using full length myc-tagged p53 as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Charles River

Curated by ChEMBL
LigandPNGBDBM50571472(CHEMBL4867495 | US11685734, Example 291)
Affinity DataKi:  2nMAssay Description:Inhibition of full length recombinant FLAG-tagged human ATM assessed as decrease in p53 S15 phosphorylation using full length myc-tagged p53 as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314780(CHEMBL1091199 | N-Cyclopropyl-3-(1-(2,4-difluoroph...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314779(CHEMBL1089457 | N-Cyclopropyl-4-methyl-3-(7-methyl...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314776(CHEMBL1089865 | N-Cyclopropyl-3-(1-(2,6-difluoroph...)
Affinity DataKi:  2.5nMAssay Description:Inhibition of p38betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Charles River

Curated by ChEMBL
LigandPNGBDBM50571461(CHEMBL4866506 | US11685734, Example 96)
Affinity DataKi:  3nMAssay Description:Inhibition of full length recombinant FLAG-tagged human ATM assessed as decrease in p53 S15 phosphorylation using full length myc-tagged p53 as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Charles River

Curated by ChEMBL
LigandPNGBDBM50571473(CHEMBL4856420 | US11685734, Example 39)
Affinity DataKi:  4nMAssay Description:Inhibition of full length recombinant FLAG-tagged human ATM assessed as decrease in p53 S15 phosphorylation using full length myc-tagged p53 as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Charles River

Curated by ChEMBL
LigandPNGBDBM50571463(CHEMBL4862803)
Affinity DataKi:  4nMAssay Description:Inhibition of full length recombinant GST-tagged human VPS34 expressed in baculovirus expression system using PI/PS as substrate incubated for 60 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Charles River

Curated by ChEMBL
LigandPNGBDBM50571446(CHEMBL4879094)
Affinity DataKi:  4nMAssay Description:Inhibition of full length recombinant FLAG-tagged human ATM assessed as decrease in p53 S15 phosphorylation using full length myc-tagged p53 as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Charles River

Curated by ChEMBL
LigandPNGBDBM50571474(CHEMBL4857803 | US11685734, Example 211)
Affinity DataKi:  5nMAssay Description:Inhibition of full length recombinant GST-tagged human VPS34 expressed in baculovirus expression system using PI/PS as substrate incubated for 60 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Charles River

Curated by ChEMBL
LigandPNGBDBM50571460(CHEMBL4858974 | US11685734, Example 98)
Affinity DataKi:  6nMAssay Description:Inhibition of full length recombinant FLAG-tagged human ATM assessed as decrease in p53 S15 phosphorylation using full length myc-tagged p53 as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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