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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50296661
Substrate
n/a
Meas. Tech.
ChEMBL_582351 (CHEMBL1053415)
IC50
1.1±n/a nM
Citation
 Wurz, RP; Pettus, LH; Xu, S; Henkle, B; Sherman, L; Plant, M; Miner, K; McBride, H; Wong, LM; Saris, CJ; Lee, MR; Chmait, S; Mohr, C; Hsieh, F; Tasker, AS Part 1: Structure-Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase. Bioorg Med Chem Lett 19:4724-8 (2009) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50296661
Synonyms:
4-chloro-N-cyclopropyl-3-(1-(2,6-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-4-ylamino)benzamide | CHEMBL564054
Type:
Small organic molecule
Emp. Form.:
C23H18ClF2N5O2
Mol. Mass.:
469.871
SMILES:
Cn1c2n(ncc2c(Nc2cc(ccc2Cl)C(=O)NC2CC2)cc1=O)-c1c(F)cccc1F |(9.5,-38.9,;9.5,-37.36,;8.17,-36.6,;6.69,-37.08,;5.78,-35.82,;6.69,-34.57,;8.17,-35.05,;9.5,-34.28,;9.5,-32.74,;10.84,-31.97,;12.16,-32.75,;13.5,-31.98,;13.5,-30.44,;12.16,-29.67,;10.83,-30.44,;9.5,-29.67,;14.83,-32.76,;14.83,-34.3,;16.17,-31.99,;17.5,-32.77,;18.26,-34.1,;19.03,-32.77,;10.83,-35.06,;10.83,-36.6,;12.16,-37.37,;6.22,-38.54,;4.71,-38.85,;3.69,-37.7,;4.24,-40.31,;5.27,-41.46,;6.78,-41.13,;7.25,-39.67,;8.76,-39.34,)|
Structure:
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