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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50296662
Substrate
n/a
Meas. Tech.
ChEMBL_582351 (CHEMBL1053415)
IC50
1.9±n/a nM
Citation
 Wurz, RP; Pettus, LH; Xu, S; Henkle, B; Sherman, L; Plant, M; Miner, K; McBride, H; Wong, LM; Saris, CJ; Lee, MR; Chmait, S; Mohr, C; Hsieh, F; Tasker, AS Part 1: Structure-Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase. Bioorg Med Chem Lett 19:4724-8 (2009) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50296662
Synonyms:
CHEMBL559242 | N-cyclopropyl-3-(1-(2,6-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-4-ylamino)-4-fluorobenzamide
Type:
Small organic molecule
Emp. Form.:
C23H18F3N5O2
Mol. Mass.:
453.4165
SMILES:
Cn1c2n(ncc2c(Nc2cc(ccc2F)C(=O)NC2CC2)cc1=O)-c1c(F)cccc1F |(25.93,-39.37,;25.93,-37.83,;24.6,-37.06,;23.13,-37.54,;22.22,-36.29,;23.13,-35.04,;24.6,-35.52,;25.93,-34.75,;25.94,-33.21,;27.27,-32.44,;28.6,-33.22,;29.93,-32.45,;29.94,-30.91,;28.6,-30.14,;27.27,-30.91,;25.93,-30.14,;31.27,-33.23,;31.26,-34.77,;32.6,-32.46,;33.93,-33.23,;34.69,-34.57,;35.47,-33.24,;27.26,-35.52,;27.26,-37.06,;28.59,-37.84,;22.65,-39.01,;21.15,-39.32,;20.12,-38.17,;20.67,-40.78,;21.71,-41.93,;23.22,-41.6,;23.69,-40.14,;25.19,-39.81,)|
Structure:
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