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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50299289
Substrate
n/a
Meas. Tech.
ChEMBL_589788 (CHEMBL1051411)
Ki
7.3±n/a nM
Citation
 Maestrup, EG; Fischer, S; Wiese, C; Schepmann, D; Hiller, A; Deuther-Conrad, W; Steinbach, J; Wünsch, B; Brust, P Evaluation of spirocyclic 3-(3-fluoropropyl)-2-benzofurans as sigma1 receptor ligands for neuroimaging with positron emission tomography. J Med Chem 52:6062-72 (2009) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50299289
Synonyms:
3-(3-Fluoropropyl)-1'-(1-phenylethyl)-3H-spiro[[2]benzofuran-1,4'-piperidine] | CHEMBL574124
Type:
Small organic molecule
Emp. Form.:
C23H28FNO
Mol. Mass.:
353.4729
SMILES:
CC(N1CCC2(CC1)OC(CCCF)c1ccccc21)c1ccccc1
Structure:
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