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Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Ligand
BDBM50299571
Substrate
n/a
Meas. Tech.
ChEMBL_591873 (CHEMBL1045943)
IC50
3420±n/a nM
Citation
 Bruno, O; Romussi, A; Spallarossa, A; Brullo, C; Schenone, S; Bondavalli, F; Vanthuyne, N; Roussel, C New selective phosphodiesterase 4D inhibitors differently acting on long, short, and supershort isoforms. J Med Chem 52:6546-57 (2009) [PubMed]  Article 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Synonyms:
3',5'-cyclic phosphodiesterase | DPDE3 | PDE43 | PDE4D | PDE4D_HUMAN | Phosphodiesterase 4D
Type:
Protein
Mol. Mass.:
91092.69
Organism:
Homo sapiens (Human)
Description:
Q08499
Residue:
809
Sequence:
MEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPPPPPSPQPQPQCPLQPPPPPPLPPPPPPPGAARGRYASSGATGRVRHRGYSDTERYLYCRAMDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDRSPDT
  
Inhibitor
Name:
BDBM50299571
Synonyms:
3-(cyclopentyloxy)-4-methoxybenzaldehyde O-[2-chloro-3-(2,6-dimethylmorpholin-4-yl)propyl]-oxime | CHEMBL570355
Type:
Small organic molecule
Emp. Form.:
C22H33ClN2O4
Mol. Mass.:
424.961
SMILES:
COc1ccc(\C=N\OCC(Cl)CN2CC(C)OC(C)C2)cc1OC1CCCC1
Structure:
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