Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM50306016
Substrate
n/a
Meas. Tech.
ChEMBL_605683 (CHEMBL1071213)
Ki
2500±n/a nM
Citation
Gilbert, EJ; Zhou, G; Wong, MK; Tong, L; Shankar, BB; Huang, C; Kelly, J; Lavey, BJ; McCombie, SW; Chen, L; Rizvi, R; Dong, Y; Shu, Y; Kozlowski, JA; Shih, NY; Hipkin, RW; Gonsiorek, W; Malikzay, A; Lunn, CA; Favreau, L; Lundell, DJ Non-aromatic A-ring replacement in the triaryl bis-sulfone CB2 receptor inhibitors. Bioorg Med Chem Lett 20:608-11 (2010) [PubMed] Article
More Info.:
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
Inhibitor
Name:
BDBM50306016
Synonyms:
CHEMBL596579 | N-(6-(4-chloro-2-(2-fluorophenylsulfonyl)phenylsulfonyl)-6-azaspiro[2.5]octan-1-yl)-1,1,1-trifluoromethanesulfonamide
Type:
Small organic molecule
Emp. Form.:
C20H19ClF4N2O6S3
Mol. Mass.:
591.016
SMILES:
Fc1ccccc1S(=O)(=O)c1cc(Cl)ccc1S(=O)(=O)N1CCC2(CC2NS(=O)(=O)C(F)(F)F)CC1